HIV-1 亚型 A 和 D 感染中不变自然杀伤 T 细胞和 FoxP3⁺调节性 T 细胞的差异丢失。
Differential loss of invariant natural killer T cells and FoxP3⁺ regulatory T cells in HIV-1 subtype A and subtype D infections.
机构信息
Makerere University Walter Reed Project, Kampala, Uganda.
出版信息
J Acquir Immune Defic Syndr. 2013 Jul 1;63(3):289-93. doi: 10.1097/QAI.0b013e31828b2073.
Abstract
HIV-1 subtype D is associated with faster disease progression compared with subtype A. Immunological correlates of this difference remain undefined. We investigated invariant natural killer T (iNKT) cells and FoxP3⁺ regulatory T cells (Tregs) in Ugandans infected with either subtype. Loss of iNKT cells was pronounced in subtype D, whereas Tregs displayed more profound loss in subtype A infection. The iNKT cell levels were associated with CD4 T-cell interleukin-2 production in subtype A, but not in D, infection. Thus, these viral subtypes are associated with differential loss of iNKT cells and Tregs that may influence the quality of the adaptive immune response.
摘要
HIV-1 型 D 亚型与 A 亚型相比，疾病进展更快。这种差异的免疫相关性仍未确定。我们在感染 A 或 D 亚型的乌干达人中研究了不变自然杀伤 T(iNKT)细胞和 FoxP3+调节性 T 细胞(Treg)。D 亚型中 iNKT 细胞的丢失更为明显，而 A 亚型感染中 Treg 的丢失更为明显。在 A 亚型感染中，iNKT 细胞水平与 CD4 T 细胞白细胞介素-2 的产生相关，但在 D 亚型感染中不相关。因此，这些病毒亚型与 iNKT 细胞和 Treg 的不同丢失有关，这可能影响适应性免疫反应的质量。
相似文献
1
Differential loss of invariant natural killer T cells and FoxP3⁺ regulatory T cells in HIV-1 subtype A and subtype D infections.
J Acquir Immune Defic Syndr. 2013 Jul 1;63(3):289-93. doi: 10.1097/QAI.0b013e31828b2073.
2
Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection.
Mucosal Immunol. 2017 Jan;10(1):69-78. doi: 10.1038/mi.2016.34. Epub 2016 Apr 6.
3
Elevated levels of invariant natural killer T-cell and natural killer cell activation correlate with disease progression in HIV-1 and HIV-2 infections.
AIDS. 2016 Jul 17;30(11):1713-22. doi: 10.1097/QAD.0000000000001147.
4
Preferential depletion of gut CD4-expressing iNKT cells contributes to systemic immune activation in HIV-1 infection.
Mucosal Immunol. 2013 May;6(3):591-600. doi: 10.1038/mi.2012.101. Epub 2012 Nov 14.
5
Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion.
J Immunol. 2016 Sep 1;197(5):1843-51. doi: 10.4049/jimmunol.1600556. Epub 2016 Aug 1.
6
Severe immune dysregulation affects CD4⁺CD25(hi)FoxP3⁺ regulatory T cells in HIV-infected patients with low-level CD4 T-cell repopulation despite suppressive highly active antiretroviral therapy.
J Infect Dis. 2012 May 15;205(10):1501-9. doi: 10.1093/infdis/jis230. Epub 2012 Mar 28.
7
Correlation between the degree of immune activation, production of IL-2 and FOXP3 expression in CD4+CD25+ T regulatory cells in HIV-1 infected persons under HAART.
Int Immunopharmacol. 2009 Jul;9(7-8):831-6. doi: 10.1016/j.intimp.2009.03.009. Epub 2009 Mar 18.
8
Bacterial CD1d-restricted glycolipids induce IL-10 production by human regulatory T cells upon cross-talk with invariant NKT cells.
J Immunol. 2013 Sep 1;191(5):2174-83. doi: 10.4049/jimmunol.1300562. Epub 2013 Jul 29.
9
Regulatory T cell expansion and immune activation during untreated HIV type 1 infection are associated with disease progression.
AIDS Res Hum Retroviruses. 2009 Feb;25(2):183-91. doi: 10.1089/aid.2008.0140.
10
Functional Invariant Natural Killer T Cells Secreting Cytokines Are Associated With Non-Progressive Human Immunodeficiency Virus-1 Infection but Not With Suppressive Anti-Retroviral Treatment.
Front Immunol. 2018 May 24;9:1152. doi: 10.3389/fimmu.2018.01152. eCollection 2018.
引用本文的文献
1
Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion.
J Immunol. 2016 Sep 1;197(5):1843-51. doi: 10.4049/jimmunol.1600556. Epub 2016 Aug 1.
2
HIV Type 1 Disease Progression to AIDS and Death in a Rural Ugandan Cohort Is Primarily Dependent on Viral Load Despite Variable Subtype and T-Cell Immune Activation Levels.
J Infect Dis. 2015 May 15;211(10):1574-84. doi: 10.1093/infdis/jiu646. Epub 2014 Nov 17.
3
Impaired natural killer cell responses are associated with loss of the highly activated NKG2A(+)CD57(+)CD56(dim) subset in HIV-1 subtype D infection in Uganda.
AIDS. 2014 Jun 1;28(9):1273-8. doi: 10.1097/QAD.0000000000000286.
本文引用的文献
1
Preferential depletion of gut CD4-expressing iNKT cells contributes to systemic immune activation in HIV-1 infection.
Mucosal Immunol. 2013 May;6(3):591-600. doi: 10.1038/mi.2012.101. Epub 2012 Nov 14.
2
Loss of effector and anti-inflammatory natural killer T lymphocyte function in pathogenic simian immunodeficiency virus infection.
PLoS Pathog. 2012 Sep;8(9):e1002928. doi: 10.1371/journal.ppat.1002928. Epub 2012 Sep 20.
3
HIV-1 Vpu interference with innate cell-mediated immune mechanisms.
Curr HIV Res. 2012 Jun;10(4):327-33. doi: 10.2174/157016212800792513.
4
Regulatory T cells: mechanisms of differentiation and function.
Annu Rev Immunol. 2012;30:531-64. doi: 10.1146/annurev.immunol.25.022106.141623. Epub 2012 Jan 6.
5
Th17 cells and regulatory T cells in elite control over HIV and SIV.
Curr Opin HIV AIDS. 2011 May;6(3):221-7. doi: 10.1097/COH.0b013e32834577b3.
6
Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments.
Blood. 2010 Sep 16;116(11):1876-84. doi: 10.1182/blood-2009-09-243667. Epub 2010 Jun 8.
7
Infection with different hiv subtypes is associated with CD4 activation-associated dysfunction and apoptosis.
J Acquir Immune Defic Syndr. 2009 Dec;52(5):548-52. doi: 10.1097/QAI.0b013e3181c1d456.
8
Lower cytokine secretion ex vivo by natural killer T cells in HIV-infected individuals is associated with higher CD161 expression.
AIDS. 2009 Sep 24;23(15):1965-70. doi: 10.1097/QAD.0b013e32832b5134.
9
Severe functional impairment and elevated PD-1 expression in CD1d-restricted NKT cells retained during chronic HIV-1 infection.
Eur J Immunol. 2009 Mar;39(3):902-11. doi: 10.1002/eji.200838780.
10
Emerging concepts in the immunopathogenesis of AIDS.
Annu Rev Med. 2009;60:471-84. doi: 10.1146/annurev.med.60.041807.123549.
Zotero 插件