Makerere University Walter Reed Project, Kampala, Uganda.
J Acquir Immune Defic Syndr. 2013 Jul 1;63(3):289-93. doi: 10.1097/QAI.0b013e31828b2073.
HIV-1 subtype D is associated with faster disease progression compared with subtype A. Immunological correlates of this difference remain undefined. We investigated invariant natural killer T (iNKT) cells and FoxP3⁺ regulatory T cells (Tregs) in Ugandans infected with either subtype. Loss of iNKT cells was pronounced in subtype D, whereas Tregs displayed more profound loss in subtype A infection. The iNKT cell levels were associated with CD4 T-cell interleukin-2 production in subtype A, but not in D, infection. Thus, these viral subtypes are associated with differential loss of iNKT cells and Tregs that may influence the quality of the adaptive immune response.
HIV-1 型 D 亚型与 A 亚型相比，疾病进展更快。这种差异的免疫相关性仍未确定。我们在感染 A 或 D 亚型的乌干达人中研究了不变自然杀伤 T(iNKT)细胞和 FoxP3+调节性 T 细胞(Treg)。D 亚型中 iNKT 细胞的丢失更为明显，而 A 亚型感染中 Treg 的丢失更为明显。在 A 亚型感染中，iNKT 细胞水平与 CD4 T 细胞白细胞介素-2 的产生相关，但在 D 亚型感染中不相关。因此，这些病毒亚型与 iNKT 细胞和 Treg 的不同丢失有关，这可能影响适应性免疫反应的质量。
