代谢综合征与血清尿酸对舒张性心力衰竭的关联与交互作用分析。
Association and interaction analysis of metabolic syndrome and serum uric acid on diastolic heart failure.
机构信息
Department of Endocrinology and Metabolism, Fudan University Huashan Hospital, No 12 Wulumuqi Mid Road, Building 0#, Jing'an District, Shanghai, 200040, China.
出版信息
J Endocrinol Invest. 2013 Sep;36(8):579-83. doi: 10.3275/8851. Epub 2013 Feb 12.
BACKGROUND
We aimed to assess the extent to which metabolic syndrome (MetS) and serum uric acid (UA) and its interaction impact on diastolic heart failure (DHF).
MATERIALS AND METHODS
A total of 133 patients with DHF and 118 age- and gender-matched control subjects were studied. Echocardiography was used to assess left ventricular (LV) diastolic function. MetS was defined by suggestions of international diabetes federation (IDF, 2005). The association between MetS or UA and DHF was assessed by multivariate logistic regression analysis (MLR) controlling confounders. The interaction between MetS and UA on DHF was assessed by generalized linear model (GLM) and MLR analysis.
RESULTS
MetS and UA were independent predictors of DHF after adjustment for all variables (OR=0.8332.27, ORUA=1.003 and p<0.05 for all). There was an interaction effect of MetS and UA on DHF (ORInt=2.412.66, pInt<0.05).
CONCLUSION
The findings of the present study suggested that MetS or UA is associated with DHF, and that MetS interacts with UA to impact on DHF.
背景
本研究旨在评估代谢综合征（MetS）及血清尿酸（UA）及其相互作用对舒张性心力衰竭（DHF）的影响程度。
材料与方法
共纳入 133 例 DHF 患者和 118 名年龄、性别匹配的对照组。采用超声心动图评估左心室（LV）舒张功能。MetS 按国际糖尿病联合会（IDF，2005 年）的建议进行定义。采用多变量逻辑回归分析（MLR）控制混杂因素评估 MetS 或 UA 与 DHF 的相关性。采用广义线性模型（GLM）和 MLR 分析评估 MetS 和 UA 对 DHF 的交互作用。
结果
校正所有变量后，MetS 和 UA 是 DHF 的独立预测因子（OR=0.8332.27，ORUA=1.003，p<0.05）。MetS 和 UA 对 DHF 有交互作用（ORInt=2.412.66，pInt<0.05）。
结论
本研究结果表明，MetS 或 UA 与 DHF 相关，MetS 与 UA 相互作用影响 DHF。
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