Department of Industrial Design, Chang Gung University, Kweishan, Taoyuan, Taiwan, ROC.
J Epidemiol. 2010;20(3):219-24. doi: 10.2188/jea.je20090078. Epub 2010 Mar 20.
Metabolic syndrome (MetS) and hyperuricemia are important risk factors for cardiovascular disease. However, findings regarding the relationship between serum uric acid (UA) level and components of MetS have been inconsistent. This study was performed to explore the potential value of UA level as a marker of MetS among male and female Chinese of different ages.
A total of 5896 subjects (2960 females and 2936 males) were recruited from the Department of Health Management at the Chang Gung Medical Center. Hyperuricemia was defined as a serum UA value >7.0 mg/dL for males or >6.0 mg/dL for females. MetS was defined according to the criteria of the Adult Treatment Panel III, as modified for Chinese subjects. Serum UA was used to differentiate MetS and to calculate epidemiological indices by means of discriminate analysis and logistic regression.
The sensitivity and specificity of serum UA concentration as a marker of MetS ranged from 55.2% to 61.4% and 61.9% to 68.4%, respectively. Subjects with high UA had a higher risk of MetS, with odds ratios ranging from 1.23 to 1.82 (P < 0.01). A positive correlation between serum UA and MetS was observed in both sexes. Serum UA and the occurrence of MetS rose with increasing age in females; in males, however, UA values did not vary with age.
Serum UA is more closely associated with MetS in females than in males. High UA among middle-aged women may predict the development of MetS.
代谢综合征（MetS）和高尿酸血症是心血管疾病的重要危险因素。然而，关于血清尿酸（UA）水平与 MetS 成分之间的关系的研究结果并不一致。本研究旨在探讨 UA 水平作为不同年龄的中国男性和女性 MetS 标志物的潜在价值。
共招募了 5896 名受试者（2960 名女性和 2936 名男性），他们来自长庚医疗中心健康管理部。高尿酸血症定义为男性血清 UA 值>7.0mg/dL 或女性>6.0mg/dL。MetS 根据成人治疗小组 III 的标准定义，适用于中国人群进行了修改。使用血清 UA 来区分 MetS，并通过判别分析和逻辑回归计算流行病学指标。
血清 UA 浓度作为 MetS 标志物的灵敏度和特异性范围分别为 55.2%至 61.4%和 61.9%至 68.4%。UA 水平高的患者发生 MetS 的风险更高，比值比范围为 1.23 至 1.82（P<0.01）。男女两性血清 UA 与 MetS 呈正相关。女性血清 UA 和 MetS 的发生随年龄的增长而增加；然而，在男性中，UA 值不随年龄变化。
血清 UA 与女性的 MetS 相关性高于男性。中年女性的高 UA 可能预示着 MetS 的发生。
