Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Heinrich Heine University Düsseldorf, Germany.
Front Immunol. 2013 Feb 7;4:27. doi: 10.3389/fimmu.2013.00027. eCollection 2013.
The antileukemic potential of natural killer (NK) cells has been of rising interest in recent years. Interactions between inhibitory killer cell immunoglobulin-like receptors (KIR) and HLA class I ligands seem to be critically involved in the immunosurveillance process. It is also well established that mismatching of HLA class I-encoded KIR ligands in the setting of hematopoietic stem cell transplantation leads to allorecognition of leukemic cells by NK cells, which is in line with the concept of missing-self recognition. Recent data now suggest that KIR gene polymorphism constitutes another important parameter that needs to be taken into account for selection of suitable stem cell donors. Moreover, the role of KIR gene polymorphism for predisposition to leukemia is a current matter of debate. Here, we would like to review the role of KIR function and genetic polymorphism for recognition of leukemia and discuss the impact of these findings for developing novel concepts for NK cell-based immunotherapy strategies.
近年来，自然杀伤 (NK) 细胞的抗白血病潜能引起了越来越多的关注。抑制性杀伤细胞免疫球蛋白样受体 (KIR) 与 HLA Ⅰ类配体之间的相互作用似乎在免疫监视过程中起着关键作用。此外，造血干细胞移植中 HLA Ⅰ类编码的 KIR 配体不匹配会导致 NK 细胞对白血病细胞的同种异体识别，这与“丢失自我”识别的概念一致。最近的数据表明，KIR 基因多态性是选择合适干细胞供体时需要考虑的另一个重要参数。此外，KIR 基因多态性对白血病易感性的作用是目前争论的焦点。在这里，我们将回顾 KIR 功能和遗传多态性对白血病识别的作用，并讨论这些发现对开发基于 NK 细胞的免疫治疗策略的新概念的影响。
