采用串联质谱法测定的成年男性睾酮及计算的游离睾酮参考范围。
Adult testosterone and calculated free testosterone reference ranges by tandem mass spectrometry.
机构信息
Department of Medical Biochemistry & Immunology, University Hospital of Wales, Heath Park, UK.
出版信息
Ann Clin Biochem. 2013 Mar;50(Pt 2):159-61. doi: 10.1258/acb.2012.012047. Epub 2013 Feb 12.
BACKGROUND
Testosterone is measured for the investigation of female hyperandrogenism and male hypogonadism. Liquid chromatography-tandem mass spectrometry (tandem MS) is becoming the method of choice but comprehensive reference ranges are lacking.
METHODS
Testosterone was measured by tandem MS on 90 healthy women, 67 young healthy men and pregnant women (59 first trimester and 60 second trimester).
RESULTS
The male, male calculated free, first trimester and second trimester testosterone reference ranges (derived using the antilog of mean ± 1.96 SD of log transformed data) were 10.6-31.9, 0.23-0.63, 0.6-4.9 and 0.9-4.9 nmol/L, respectively. The female testosterone upper reference range limit, derived non-parametrically from the 97.5th centile, was <1.7 nmol/L.
CONCLUSIONS
We have derived tandem MS testosterone reference ranges to support clinical services.
背景
睾酮用于女性高雄激素血症和男性低促性腺激素性性腺功能减退症的检查。液相色谱-串联质谱（串联质谱）正成为首选方法，但缺乏全面的参考范围。
方法
采用串联质谱法对 90 名健康女性、67 名年轻健康男性和孕妇（59 名孕早期和 60 名孕中期）进行了睾酮检测。
结果
男性、男性计算游离、孕早期和孕中期睾酮参考范围（采用对数转换后数据的均值±1.96SD 的反对数得出）分别为 10.6-31.9、0.23-0.63、0.6-4.9 和 0.9-4.9 nmol/L。女性睾酮的上参考范围限值是<1.7 nmol/L，这是通过非参数法从第 97.5 百分位数推导出来的。
结论
我们已经得出了串联质谱睾酮参考范围，以支持临床服务。
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