Polák J, Fuchs B, Erban J, Kubík A
Výzkumný ustav tuberkulózy a respiracních nemocí, Praha.
Cas Lek Cesk. 1990 Mar 16;129(11):329-33.
A total of 440 women with morphologically tested primary bronchogenic carcinoma were hospitalized in 1961-1987. The patients' average age was 57 years, 22% persons were under 50 years. In 32% women carcinoma was found accidentally in the asymptomatic stage of the illness, 4% women had subjective complaints which they considered insignificant, however, subjective complaints in 64% patients helped to diagnose it. The most frequent complaints were temperature, breathlessness, chest pain and loss of weight. In 2% women, the first sign was hemoptysis found most frequently as an isolated symptom. The history of 9.5% patients showed pulmonary TB, in 27% women bronchogenic carcinoma was first regarded as pulmonary TB and treated with anti-tuberculotics. The family history of 32% patients showed malignant diseases, most frequently gastric carcinoma, while bronchogenic carcinoma was found in 5.7%, of family members. The group consisted of 46% smokers and 54% non-smokers. The women smokers had smoked for 29 years on average, had smoked 205 thousand cigarettes on average, the average daily amount was 20 cigarettes. Regardless of their smoking habits, the most frequent histological type was found to be adenocarcinoma in 47% cases, with the squamous-cell type prevailing in the smokers (37%), and adenocarcinoma in non-smokers (59%). 36% of the patients underwent surgery, the most frequent contraindication for surgery were generalization of the process and lymph node metastases. Lobectomy was the most common operation performed (62%). 5 patients died within the first post-operative month.
1961年至1987年期间,共有440名经形态学检测确诊为原发性支气管癌的女性患者住院治疗。患者的平均年龄为57岁,22%的患者年龄在50岁以下。32%的女性患者是在疾病无症状阶段偶然发现癌症的,4%的女性患者有一些她们认为不严重的主观症状,然而,64%的患者的主观症状有助于诊断疾病。最常见的症状是发热、呼吸困难、胸痛和体重减轻。2%的女性患者,首发症状是咯血,咯血最常作为孤立症状出现。9.5%的患者有肺结核病史,27%的女性患者原发性支气管癌最初被误诊为肺结核并接受抗结核治疗。32%的患者家族史中有恶性疾病,最常见的是胃癌,而家族成员中发现支气管癌的比例为5.7%。该组患者中46%为吸烟者,54%为非吸烟者。吸烟女性平均吸烟29年,平均吸烟20.5万支,平均每日吸烟量为20支。无论吸烟习惯如何,最常见的组织学类型是腺癌,占47%,鳞状细胞癌在吸烟者中占主导地位(37%),在非吸烟者中腺癌占主导地位(59%)。36%的患者接受了手术,手术最常见的禁忌症是病情扩散和淋巴结转移。肺叶切除术是最常见的手术方式(62%)。5名患者在术后第一个月内死亡。