Department of Pathology, University of Göttingen, Göttingen, Germany.
Diagn Pathol. 2013 Feb 14;8:23. doi: 10.1186/1746-1596-8-23.
Sertoliform cystadenoma of the rete testis represents an uncommon benign tumour. They appear in patients from 26 to 62 years of age. We describe a case of a 66-year-old man with a tumour in the area of the epididymal head. The tumour markers were not increased. Under the assumption of a malignant testicular tumour an inguinal orchiectomy was performed. The cut surface of this tumour was of grey/white color and showed small cysts. The tumour consisted of two compartments. The epithelial like tumour cells showed a sertoliform growth pattern and cystic dilatations. In between the tumour cells repeatedly actin expressing sclerotic areas could be recognized as the second tumour component. Proliferative activity was not increased. Immunohistochemically the tumour cells were positiv for inhibin, S-100, and CD 99. Alpha feto protein (AFP), human chorionic gonadotropin (ß-HCG) and placental alkaline phosphatase (PLAP) as well as synaptophysin, epithelial membrane antigene (EMA), and BCL-2 were not expressed. As far as we know this is the sixth reported case of this tumour. Because of the benign nature of this tumour the correct diagnosis is important for the intra- and postoperative management. Here we present a case of this rare tumour and discuss potential differential diagnosis.
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睾丸网的支持细胞囊腺瘤是一种罕见的良性肿瘤。它们发生于 26 至 62 岁的患者。我们描述了一例 66 岁男性患者，其附睾头部有一个肿瘤。肿瘤标志物未升高。考虑为睾丸恶性肿瘤，行腹股沟睾丸切除术。该肿瘤的切面呈灰/白色，有小囊肿。肿瘤由两个隔室组成。上皮样肿瘤细胞呈支持细胞样生长模式和囊性扩张。在肿瘤细胞之间，反复出现表达肌动蛋白的硬化区，可以识别为第二个肿瘤成分。增殖活性没有增加。免疫组织化学染色显示肿瘤细胞对抑制素、S-100 和 CD99 阳性。α-胎儿蛋白 (AFP)、人绒毛膜促性腺激素 (β-HCG) 和胎盘碱性磷酸酶 (PLAP) 以及突触素、上皮膜抗原 (EMA) 和 BCL-2 均不表达。据我们所知，这是第六例此类肿瘤的报道。由于该肿瘤的良性性质，正确的诊断对于手术的围手术期管理很重要。在此，我们报告一例罕见的此类肿瘤，并讨论潜在的鉴别诊断。
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