Batchelder A W, Brisbane M, Litwin A H, Nahvi S, Berg K M, Arnsten J H
a Division of General Internal Medicine , Albert Einstein College of Medicine and Montefiore Medical Center , Bronx , NY , USA.
AIDS Care. 2013;25(11):1370-4. doi: 10.1080/09540121.2013.766303. Epub 2013 Feb 13.
Active drug use among HIV-infected persons is associated with poor adherence to highly active antiretroviral therapy (HAART) and suboptimal treatment outcomes. To understand adherence experiences among HIV-infected drug users, we conducted semistructured interviews with 15 participants in a randomized controlled trial evaluating the efficacy of directly observed HAART delivered in methadone maintenance clinics. Interviews were recorded, transcribed, and thematically analyzed. We identified negative and positive psychological themes associated with both drug use and adherence. Participants described tension between negative feelings (denial, shame, and perceived isolation) and positive feelings (acceptance, motivation, empowerment, and perceived connectedness), and they associated this tension with their own drug using and adherence behaviors. Sustained antiretroviral therapy adherence may require increased emphasis on understanding the psychological experience of HIV-infected drug users.
感染艾滋病毒者中存在的药物滥用问题与高效抗逆转录病毒疗法（HAART）的依从性差以及治疗效果欠佳有关。为了解感染艾滋病毒的吸毒者的依从性情况，我们对一项随机对照试验中的15名参与者进行了半结构化访谈，该试验旨在评估在美沙酮维持治疗诊所提供的直接观察下的高效抗逆转录病毒疗法的疗效。访谈进行了录音、转录并进行了主题分析。我们确定了与药物使用和依从性相关的消极和积极心理主题。参与者描述了消极情绪（否认、羞耻和感到孤立）与积极情绪（接受、动力、赋权和感到有联系）之间的紧张关系，并将这种紧张关系与他们自己的药物使用和依从行为联系起来。持续坚持抗逆转录病毒治疗可能需要更加重视理解感染艾滋病毒的吸毒者的心理体验。
