干性年龄相关性黄斑变性的视网膜微环境失衡：综述
Retinal microenvironment imbalance in dry age-related macular degeneration: a mini-review.
机构信息
Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
出版信息
Gerontology. 2013;59(4):297-306. doi: 10.1159/000346169. Epub 2013 Feb 8.
Abstract
BACKGROUND
Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. To prevent what will certainly be a tremendous health and economic burden, effective therapeutics for AMD are urgently needed. To develop these agents in a timely fashion, the molecular pathways that cause disease progression must be elucidated.
OBJECTIVE
To briefly describe the clinical features of AMD, and review the current understanding of the molecular basis of AMD.
METHODS
A literature review.
RESULTS
The discussion will primarily focus on the interplay of oxidative stress and complement dysregulation and the resulting chronic proinflammatory state thought to be central in AMD pathogenesis.
CONCLUSIONS
Oxidative stress and complement dysregulation play a substantive role in the development of AMD.
摘要
背景
年龄相关性黄斑变性（AMD）是西方世界致盲的主要原因。为了预防这一必然给健康和经济带来的巨大负担，迫切需要有效的 AMD 治疗方法。为了及时开发这些药物，必须阐明导致疾病进展的分子途径。
目的
简要描述 AMD 的临床特征，并综述 AMD 的分子基础的现有认识。
方法
文献复习。
结果
讨论将主要集中在氧化应激和补体失调的相互作用以及由此产生的慢性炎症前状态上，这被认为是 AMD 发病机制的核心。
结论
氧化应激和补体失调在 AMD 的发展中起重要作用。
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