肺干/祖细胞。
Lung stem and progenitor cells.
机构信息
Duke Cardiovascular Research Center and Mandel Center for Hypertension and Atherosclerosis Research, Duke University Medical Center, Durham, NC, USA.
出版信息
Respiration. 2013;85(2):89-95. doi: 10.1159/000346500. Epub 2013 Feb 11.
Abstract
Over the past few years, new insights have been added to the study of stem cells in the adult lung. The exploration of endogenous lung progenitors as well as the study of exogenously delivered stem cell populations holds promise for advancing our understanding of the biology of lung repair mechanisms. Moreover, it opens new possibilities for the use of stem cell therapy for the development of regenerative medicine approaches for the treatment of lung disease. Here, we discuss the main types of lung epithelial progenitor populations; the potential of endothelial progenitors, mesenchymal stem cells and embryonic stem cells for lung therapy, as well as summarize the cellular mechanisms involved.
摘要
在过去的几年中，人们对成人肺部中的干细胞研究有了新的认识。探索内源性肺祖细胞以及研究外源性干细胞群体，有望增进我们对肺修复机制生物学的理解。此外，这为利用干细胞疗法开发治疗肺部疾病的再生医学方法提供了新的可能。在这里，我们讨论了主要类型的肺上皮祖细胞群体；内皮祖细胞、间充质干细胞和胚胎干细胞在肺治疗中的潜力，并总结了所涉及的细胞机制。
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Mesenchymal stromal cells: new directions.间质基质细胞：新方向。
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