Department of Genetics, Stem Cell Program, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.
Mol Ther. 2012 Jun;20(6):1116-30. doi: 10.1038/mt.2012.37. Epub 2012 Mar 6.
A number of novel approaches for repair and regeneration of injured lung have developed over the past several years. These include a better understanding of endogenous stem and progenitor cells in the lung that can function in reparative capacity as well as extensive exploration of the potential efficacy of administering exogenous stem or progenitor cells to function in lung repair. Recent advances in ex vivo lung engineering have also been increasingly applied to the lung. The current status of these approaches as well as initial clinical trials of cell therapies for lung diseases are reviewed below.
在过去的几年中，已经开发出许多用于修复和再生受损肺部的新方法。这些方法包括对肺部内源性干细胞和祖细胞的更好理解，这些细胞可以发挥修复功能，以及广泛探索外源性干细胞或祖细胞在肺修复中发挥作用的潜在疗效。体外肺工程的最新进展也越来越多地应用于肺部。下面回顾了这些方法的现状以及细胞疗法治疗肺部疾病的初步临床试验。
