Vitols A V, Skarda I J, Liepinia D J, Voita D U, Skards J V
Latvian Research Institute of Cardiology, Riga, USSR.
Cor Vasa. 1990;32(1):36-44.
In 40 patients with essential hypertension, the authors studied the haemodynamic resistance in forearm vessels before and after 15-min arterial occlusion, and changes in this parameter during a three-year combined antihypertensive treatment. The study revealed that the 15-min occlusion did not entirely suppress the contractile activity of vascular smooth muscles. Under these conditions, the minimum vascular resistance reflects the sum of structural and functional alterations. The character of change in minimal haemodynamic vascular resistance depends on the mechanism of action of the antihypertensive drugs. Administration of the post-synaptic alpha-adrenergic blocker Pratsiol produces a decrease in the minimal haemodynamic vascular resistance.
在40例原发性高血压患者中，作者研究了15分钟动脉闭塞前后前臂血管的血流动力学阻力，以及在三年联合抗高血压治疗期间该参数的变化。研究表明，15分钟的闭塞并未完全抑制血管平滑肌的收缩活动。在这些情况下，最小血管阻力反映了结构和功能改变的总和。最小血流动力学血管阻力的变化特征取决于抗高血压药物的作用机制。给予突触后α-肾上腺素能阻滞剂普拉西奥可使最小血流动力学血管阻力降低。
