Imai Y, Abe K, Otsuka Y, Irokawa N, Yasujima M, Saito K, Sakurai Y, Chiba S, Ito T, Sato M, Haruyama T, Miura Y, Yoshinaga K
Arzneimittelforschung. 1980;30(4):674-8.
The hypotensive effect of nifedipine was studied in 9 patients with severe hypertension. After oral administration of 20 mg nifedipine mean arterial pressure (MAP) fell, reaching lowest values about 1 h p.a. The antihypertensive effect lasted 7 h. Treatment with nifedipine alone (80 mg/day) lowered MAP significantly on the first day, but it tended to rise again therealter. Addition of clonidine (450 micrograms/day) or propranolol (120 mg/day) enhanced the hypotensive effect. Furosemide (120 mg/day) was ineffective when added to the above described regimen. Without nifedipine the combine drugs failed to keep MAP down. The decrease of MAP observed when giving this combination of drugs was associated with a significant fall in total peripheral resistance and plasma renin activity, but did not alter cardiac output and blood volume. We concluded that nifedipine together with clonidine or propranolol is very effective in the management of severe hypertension.
对9例重度高血压患者研究了硝苯地平的降压作用。口服20mg硝苯地平后，平均动脉压（MAP）下降，约1小时后降至最低值。降压作用持续7小时。单独使用硝苯地平治疗（80mg/天）在第一天可显著降低MAP，但此后有再次上升的趋势。加用可乐定（450μg/天）或普萘洛尔（120mg/天）可增强降压作用。呋塞米（120mg/天）加入上述治疗方案无效。无硝苯地平时，联合用药不能使MAP降低。给予该药物组合时观察到的MAP下降与总外周阻力和血浆肾素活性显著降低有关，但不改变心输出量和血容量。我们得出结论，硝苯地平与可乐定或普萘洛尔联合应用对重度高血压的治疗非常有效。
