Wu Q Z
Sichuan Institute of Industrial Hygiene and Occupational Diseases, Chengdu.
Zhonghua Yu Fang Yi Xue Za Zhi. 1990 Jan;24(1):19-21.
This paper describes teratogenic studies of stannous chloride in rats. The compound was administered to pregnant rats on gestational days 7 through 12 orally by a stomach tube at dose levels of 0 mg, 20 mg, 100 mg, 500 mg/kg of stannous chloride and fish liver oil for the positive control group. The experimental results showed that the placenta not only retains some stannous chloride but also diverts parts of the stannous chloride is the fetus. Stannous chloride showed teratogenic effects on the early growing embryos and protruding tongue of fetus.
本文描述了氯化亚锡对大鼠的致畸研究。通过胃管在妊娠第7至12天经口给怀孕大鼠施用该化合物，剂量水平为0毫克、20毫克、100毫克、500毫克/千克氯化亚锡，阳性对照组施用鱼肝油。实验结果表明，胎盘不仅保留了一些氯化亚锡，还将部分氯化亚锡转移到胎儿体内。氯化亚锡对早期发育的胚胎和胎儿的舌头突出有致畸作用。
