M Elliott Perry, A Mohiddin Saidi
The Heart Hospital, 16-18 Westmoreland Street, London; UK.
Acta Inform Med. 2011 Dec;19(4):235-40. doi: 10.5455/aim.2011.19.235-240.
As we approach the end of 2011 it is clear that the next few years are going to be dominated by the application of new high throughput genetic screening techniques, capable of screening the entire exome or indeed genome. Understanding the data generated by these techniques will require new and equally sophisticated analysis of large and complex datasets, using a systems biology approach with deeper phenotyping and advanced modelling techniques that have the flexibility for continuous update, refinement with discovery of new knowledge. Exciting new developments that may also transform cardiomyopathy research include those of infrastructure and organisation (multi-centre collaborations) and spin-offs from the field of regenerative medicine research. For clinical researchers that translate this information to the clinic the focus will however remain the same; namely improvement of quality and quantity of life.
随着我们临近2011年末，很明显未来几年将由新的高通量基因筛选技术的应用主导，这些技术能够筛选整个外显子组甚至基因组。要理解这些技术产生的数据，将需要采用系统生物学方法，运用更深入的表型分析和先进的建模技术，对庞大而复杂的数据集进行同样复杂的新分析，这些技术具有持续更新、随着新知识的发现而不断完善的灵活性。可能同样会改变心肌病研究的令人兴奋的新进展包括基础设施和组织方面（多中心合作）以及再生医学研究领域衍生出的成果。然而，对于将这些信息转化应用于临床的临床研究人员来说，重点仍将保持不变；即提高生活质量和数量。
