致畸物筛查：当前技术水平
Teratogen screening: state of the art.
作者信息
Schumann Julia
机构信息
Faculty of Veterinary Medicine, Institute of Physiological Chemistry, University of Leipzig, Leipzig, Germany.
出版信息
Avicenna J Med Biotechnol. 2010 Jul;2(3):115-21.
Abstract
Due to the number of new substances coming into use every year and the increasing amounts of chemicals, which are introduced into the environment, there is a high demand for a rapid, reliable and cost-effective method for detection of developmental toxicity. To meet this challenge various in vitro techniques have been established additional to in vivo animal testing. This review introduces the techniques in existence at the moment. Requirements on an ideal in vitro teratogenicity test system are stated, and the advantages and disadvantages of the present methods are discussed.
摘要
由于每年投入使用的新物质数量众多，以及引入环境中的化学物质数量不断增加，因此对一种快速、可靠且具有成本效益的发育毒性检测方法有很高的需求。为应对这一挑战，除了体内动物试验外，还建立了各种体外技术。本综述介绍了目前现有的技术。阐述了理想的体外致畸性测试系统的要求，并讨论了现有方法的优缺点。
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