Department of Medicine, Division of Dermatology, University of Washington, Seattle, Washington, DC 98195-6524, USA.
Anat Rec (Hoboken). 2013 Mar;296(3):521-32. doi: 10.1002/ar.22660.
Recent studies of mice with hair defects have resulted in major contributions to the understanding of hair disorders. To use mouse models as a tool to study nail diseases, a basic understanding of the similarities and differences between the human and mouse nail unit is required. In this study we compare the human and mouse nail unit at the macroscopic and microscopic level and use immunohistochemistry to determine the keratin expression patterns in the mouse nail unit. Both species have a proximal nail fold, cuticle, nail matrix, nail bed, nail plate, and hyponychium. Distinguishing features are the shape of the nail and the presence of an extended hyponychium in the mouse. Expression patterns of most keratins are similar. These findings indicate that the mouse nail unit shares major characteristics with the human nail unit and overall represents a very similar structure, useful for the investigation of nail diseases and nail biology.
最近对毛发缺陷小鼠的研究对理解毛发疾病做出了重大贡献。为了将小鼠模型用作研究指甲疾病的工具，需要基本了解人指甲单位和小鼠指甲单位之间的异同。在这项研究中，我们在宏观和微观水平上比较了人指甲单位和小鼠指甲单位，并使用免疫组织化学来确定小鼠指甲单位中的角蛋白表达模式。这两个物种都有近端甲褶、角质层、甲母质、甲板、甲床和甲下皮。区别特征是指甲的形状和小鼠中延伸的甲下皮的存在。大多数角蛋白的表达模式相似。这些发现表明，小鼠指甲单位与人指甲单位具有主要特征，总体上代表了非常相似的结构，可用于研究指甲疾病和指甲生物学。
