血凝素裂解位点的单个氨基酸有助于埃及高致病性 H5N1 流感病毒在鸡中的致病性，但不影响其传播。
A single amino acid at the hemagglutinin cleavage site contributes to the pathogenicity but not the transmission of Egyptian highly pathogenic H5N1 influenza virus in chickens.
机构信息
Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
出版信息
J Virol. 2013 Apr;87(8):4786-8. doi: 10.1128/JVI.03551-12. Epub 2013 Feb 13.
Abstract
Highly pathogenic avian influenza (HPAI) virus H5N1 has been enzootic in Egypt since 2008. Virus-associated mortality (but not the number of cases) in humans and poultry seems to have decreased over time, but the reason for this remains unknown. We investigated the role of a single amino acid substitution in the hemagglutinin cleavage site on virus pathogenicity and transmission in chickens. The R325G substitution significantly reduced pathogenicity without altering the transmission efficiency of HPAI H5N1 virus.
摘要
高致病性禽流感（HPAI）病毒 H5N1 自 2008 年以来一直在埃及流行。人类和家禽中与病毒相关的死亡率（但不是病例数）似乎随时间的推移而降低，但原因尚不清楚。我们研究了血凝素裂解位点单个氨基酸取代在鸡中对病毒致病性和传播的作用。R325G 取代显著降低了致病性，而不改变 HPAI H5N1 病毒的传播效率。
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本文引用的文献
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