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Iodine increases and predicts incidence of thyroiditis in NOD mice: Histopathological and ultrastructural study.

作者信息

Vecchiatti Stella Maria Pedrossian, Guzzo Maria Luisa, Caldini Elia Garcia, Bisi Hélio, Longatto-Filho Adhemar, Lin Chin Jia

机构信息

Department of Pathology, University of São Paulo School of Medicine, University of São Paulo, São Paulo, Brazil ; ; Endocrinology Service of Municipal Hospital of São Paulo, University of São Paulo, São Paulo, Brazil ;

出版信息

Exp Ther Med. 2013 Feb;5(2):603-607. doi: 10.3892/etm.2012.826. Epub 2012 Nov 22.

DOI:10.3892/etm.2012.826
PMID:23408765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3570204/
Abstract

Prolonged intake of large amounts of iodine has been reported to increase the incidence of hypothyroidism in humans, as well as in animals which are prone to spontaneously developing autoimmune thyroiditis. We sought to investigate the histopathological consequences of large amounts of dietary iodine on the thyroid gland and observe the occurrence of lymphocytic infiltration associated with the time of exposure to iodine. An experimental model using non-obese diabetic (NOD) mice was analyzed. A potassium iodide intake of 0.2 mg/animal/day was administered via drinking water, in experimental groups of 60 and 90 days (EG60 and EG90). Distended rough endoplasmic reticulum, degenerated mitochondria, debris and amorphous spaces or 'ill-defined' spaces were observed with electron microscopy (EM). Lymphocyte infiltration was observed in the two groups and the time of exposure to iodine did not increase the appearance of lymphocyte infiltration but significantly associated with the development of necrosis. The results of the present study demonstrated that the NOD mouse is a feasible experimental model for thyroiditis induced by iodine administration and may represent an opportunity to analyze the steps and factors associated with genetic autoimmune thyroiditis. High doses of ingested iodine were observed to precdict and increase the incidence of the thyroiditis process.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f8/3570204/7980b70c4296/ETM-05-02-0603-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f8/3570204/20188df73ef6/ETM-05-02-0603-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f8/3570204/e1323d2bbb98/ETM-05-02-0603-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f8/3570204/ed7353fdde58/ETM-05-02-0603-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f8/3570204/dc13229ff0aa/ETM-05-02-0603-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f8/3570204/1b79ecbc6ee1/ETM-05-02-0603-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f8/3570204/84b9aa106d05/ETM-05-02-0603-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f8/3570204/6b7aac02ce51/ETM-05-02-0603-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f8/3570204/7980b70c4296/ETM-05-02-0603-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f8/3570204/20188df73ef6/ETM-05-02-0603-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f8/3570204/e1323d2bbb98/ETM-05-02-0603-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f8/3570204/ed7353fdde58/ETM-05-02-0603-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f8/3570204/dc13229ff0aa/ETM-05-02-0603-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f8/3570204/1b79ecbc6ee1/ETM-05-02-0603-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f8/3570204/84b9aa106d05/ETM-05-02-0603-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f8/3570204/6b7aac02ce51/ETM-05-02-0603-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f8/3570204/7980b70c4296/ETM-05-02-0603-g07.jpg

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Thyroid and the environment: exposure to excessive nutritional iodine increases the prevalence of thyroid disorders in Sao Paulo, Brazil.甲状腺与环境：巴西圣保罗地区，过量摄入碘营养增加甲状腺疾病患病率
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Histopathology of the thyroid in amiodarone-induced hypothyroidism.
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Monitoring the effects of iodine prophylaxis in the adult population of southern Italy with deficient and sufficient iodine intake levels: a cross-sectional, epidemiological study.监测意大利南部碘摄入量不足和充足的成年人群中碘预防的效果：一项横断面流行病学研究。
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