Igarashi A, Takehara K, Soma Y, Kikuchi K, Ishibashi Y
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
Dermatologica. 1990;180(3):136-40. doi: 10.1159/000248013.
Clinical significance of specific antinuclear antibodies (ANA) in Japanese patients with systemic sclerosis was studied. The patients with systemic sclerosis were classified into four groups according to ANA: (1) anticentromere antibody-positive; (2) anti-Scl-70 antibody-positive; (3) anti-nRNP antibody-positive, and (4) others. The mean score (the number of positive signs in six selected specific signs) of the patients with anti-Scl-70 antibody was significantly higher than those of the other three groups. More frequent contracture of phalanges in the patients with anti-Scl-70 antibody, less diffuse pigmentation in the patients with anti-nRNP antibody, and less pulmonary fibrosis in the patients with anticentromere antibody were revealed. As shown above, the detection of specific ANA in systemic sclerosis is clinically important.
研究了日本系统性硬化症患者中特异性抗核抗体（ANA）的临床意义。系统性硬化症患者根据ANA分为四组：（1）抗着丝点抗体阳性；（2）抗Scl-70抗体阳性；（3）抗nRNP抗体阳性，以及（4）其他。抗Scl-70抗体患者的平均评分（六个选定特定体征中的阳性体征数量）显著高于其他三组。抗Scl-70抗体患者的指骨挛缩更频繁，抗nRNP抗体患者的弥漫性色素沉着较少，抗着丝点抗体患者的肺纤维化较少。如上所示，系统性硬化症中特异性ANA的检测具有重要临床意义。
