Legesse Teklu Bekele, Schneider Jakob
Department of Pathology, AHRI, Addis Ababa, Ethiopia.
Ethiop Med J. 2011 Oct;49(4):313-22.
Malignant melanoma is an aggressive tumor defined by some histopathologic variables which dictate its behavior and vary in different populations. To date, no data exist on these histopathologic characteristics in Ethiopian Patients.
To describe histopathologic features of primary cutaneous melanoma in Ethiopian patients.
In an attempt to define these features, histologic slides and patient record forms of cases diagnosed as primary cutaneous malignant melanoma were retrieved from records of the Pathology Department of Tikur Anbessa Specialized Teaching Hospital. From the patient records demographic variables including age, sex and anatomic location were documented. The histologic slides were revised for pathologic parameters like, histologic type, depth of invasion, host lymphocytic infiltration and pigmentation.
A total of 50 cases of primary cutaneous malignant melanoma were diagnosed in the period of 1999-2005 in Tikur Anbesa Hospital, pathology department. There were equal numbers of male and female patients; the mean age was 51.6 years. Most of the melanomas (64%) were located on the foot. The vast majority (96%) of the cases were nodular melanomas while there was one case of acral lentiginous melanoma and another case of superficial spreading melanoma. Seven (14%) were nonpigmented melanomas. The prognosis was poor with 72% of the cases showing Clark level V invasion and mean Breslow tumor thickness of 6.02mm. Ulceration was present in the majority (83.3%) of the cases.
Melanoma in Ethiopian patients is characterized by late stage presentation associated with poor prognosis and high preponderance to the foot. The higher prevalence of nodular melanomas with deep vertical invasion support the argument that this type might be a result of progression of other forms as most of our cases were late stage melanomas.
恶性黑色素瘤是一种侵袭性肿瘤，由一些组织病理学变量定义，这些变量决定其行为，且在不同人群中有所不同。迄今为止，尚无关于埃塞俄比亚患者这些组织病理学特征的数据。
描述埃塞俄比亚患者原发性皮肤黑色素瘤的组织病理学特征。
为了确定这些特征，从提库尔·安贝萨专科医院病理科的记录中检索诊断为原发性皮肤恶性黑色素瘤病例的组织学切片和患者记录表格。从患者记录中记录年龄、性别和解剖位置等人口统计学变量。对组织学切片进行病理参数检查，如组织学类型、浸润深度、宿主淋巴细胞浸润和色素沉着。
1999年至2005年期间，提库尔·安贝萨医院病理科共诊断出50例原发性皮肤恶性黑色素瘤。男性和女性患者数量相等；平均年龄为51.6岁。大多数黑色素瘤（64%）位于足部。绝大多数病例（96%）为结节性黑色素瘤，1例为肢端雀斑样黑色素瘤，另1例为浅表扩散性黑色素瘤。7例（14%）为无色素性黑色素瘤。预后较差，72%的病例显示克拉克V级浸润，平均 Breslow肿瘤厚度为6.02mm。大多数病例（83.3%）存在溃疡。
埃塞俄比亚患者的黑色素瘤特征为晚期表现，预后较差，且足部发病率较高。结节性黑色素瘤伴深部垂直浸润的较高患病率支持了这种类型可能是其他形式进展的结果这一观点，因为我们的大多数病例为晚期黑色素瘤。
