Vassileiou A, Vlastarakos P V, Kandiloros D, Delicha E, Ferekidis E, Tzagaroulakis A, Nikolopoulos T P
1st ENT Department, University of Athens, Hippokrateion General Hospital, Athens, Greece.
B-ENT. 2012;8(4):273-8.
To investigate the role of smoking, alcohol, coffee consumption, demographic factors, toxic agents, and occupation in laryngeal carcinogenesis.
MATERIALS/METHODS: A case-control study included 70 patients with histologically confirmed laryngeal cancer and 70 controls with non-neoplastic conditions unrelated to diet/smoking/alcohol. Relative risk, odds ratio (OR), and 95% confidence intervals were estimated using multiple logistic regression.
Current smokers had 19.46 OR of laryngeal cancer compared to non-smokers (p = 0.006). The respective OR for alcohol consumption was 3.94 (p = 0.006). While the risk increased in heavy drinkers, there was no difference in duration of alcohol consumption. There was a strong and consistent relation between laryngeal cancer and the consumption of Greek/Turkish coffee cups/day (p = 0.002, OR = 1.77). Diesel exhaust fumes also seemed to increase the risk of laryngeal cancer, although the association was found to be no longer significant after analysis with logistic regression.
The present study confirmed the relation of smoking and alcohol with laryngeal cancer. However, other factors such as coffee and diesel exhaust fumes may play an important role in laryngeal carcinogenesis.
探讨吸烟、饮酒、咖啡饮用、人口统计学因素、有毒物质及职业在喉癌发生中的作用。
材料/方法：一项病例对照研究纳入了70例经组织学确诊的喉癌患者和70例患有与饮食/吸烟/饮酒无关的非肿瘤性疾病的对照者。采用多因素logistic回归估计相对危险度、比值比（OR）及95%置信区间。
与不吸烟者相比，当前吸烟者患喉癌的OR为19.46（p = 0.006）。饮酒的相应OR为3.94（p = 0.006）。虽然重度饮酒者的风险增加，但饮酒持续时间并无差异。喉癌与每天饮用希腊/土耳其咖啡杯数之间存在强烈且一致的关联（p = 0.002，OR = 1.77）。柴油废气似乎也会增加患喉癌的风险，不过经logistic回归分析后发现该关联不再显著。
本研究证实了吸烟和饮酒与喉癌的关系。然而，咖啡和柴油废气等其他因素可能在喉癌发生中起重要作用。
