Ronco Claudio, Ricci Zaccaria
Crit Care. 2013 Feb 13;17(1):117. doi: 10.1186/cc12488.
Kashani and colleagues studied two novel markers, insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinases-2, in the urine of patients at high risk of acute kidney injury (AKI). They validated these markers in a separate large multicenter study and compared them with known markers of AKI such as neutrophil gelatinase-associated lipocalin and kidney injury molecule-1. Insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinases-2 performed better than other known markers and their combination provided additional information. These markers could be useful in clinical practice to uncover silent episodes of AKI or to make an early identification of patients at risk. Ultimately they could help to detect and possibly prevent episodes of acute injury to the kidney, sometimes referred to as kidney attack.
卡沙尼及其同事研究了急性肾损伤（AKI）高危患者尿液中的两种新型标志物，即胰岛素样生长因子结合蛋白7和金属蛋白酶组织抑制剂-2。他们在另一项大型多中心研究中验证了这些标志物，并将其与AKI的已知标志物（如中性粒细胞明胶酶相关脂质运载蛋白和肾损伤分子-1）进行比较。胰岛素样生长因子结合蛋白7和金属蛋白酶组织抑制剂-2的表现优于其他已知标志物，二者联合使用可提供更多信息。这些标志物在临床实践中可能有助于发现AKI的隐匿发作或早期识别高危患者。最终，它们可能有助于检测并有可能预防急性肾损伤发作，有时也称为“肾攻击”。
