Bosetti Michela, Sabbatini Maurizio, Nicolì Elena, Fusaro Luca, Cannas Mario
Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale A. Avogadro, Alessandria, Novara, Vercelli, Italy.
Growth Factors. 2013 Apr;31(2):57-65. doi: 10.3109/08977194.2013.770392. Epub 2013 Feb 15.
The importance of the complex interrelated regulatory pathways involving IGF factors and pancreatic hormones can be observed in several metabolic diseases, where the deregulation of these factors has a wide impact on bone health. These findings have stimulated us to compare the effect of IGF-I, IGF-II, insulin and preptin on human bone cells. The effect on cell differentiation and cell activity of osteoblasts and osteoclasts has been analysed. We have observed a significant effect by IGF-I, a modest effect by IGF-II and preptin and no effect after insulin administration on human primary osteoblast-like cells. All studied factors have shown an induction on human primary osteoclast differentiation and bone resorption activity, with IGF-I being the most potent factor. We hypothesize that these findings may be on the basis of decreased bone mass density observed in several diseases.
涉及胰岛素样生长因子（IGF）和胰腺激素的复杂相互关联的调节途径的重要性，在几种代谢性疾病中可见一斑，在这些疾病中，这些因子的失调对骨骼健康有广泛影响。这些发现促使我们比较IGF-I、IGF-II、胰岛素和前胰岛素原对人骨细胞的作用。分析了它们对成骨细胞和破骨细胞的细胞分化和细胞活性的影响。我们观察到IGF-I对人原代成骨样细胞有显著作用，IGF-II和前胰岛素原有适度作用，而胰岛素给药后无作用。所有研究的因子都显示出对人原代破骨细胞分化和骨吸收活性有诱导作用，其中IGF-I是最有效的因子。我们推测这些发现可能是几种疾病中观察到的骨密度降低的基础。
