Ungureanu Maria-Christina, Bilha Stefana Catalina, Hogas Mihai, Velicescu Cristian, Leustean Letitia, Teodoriu Laura Claudia, Preda Cristina
Endocrinology Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Physiology Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Metabolites. 2023 Sep 4;13(9):991. doi: 10.3390/metabo13090991.
Preptin is a 34-aminoacid peptide derived from the E-peptide of pro-insulin-like growth factor 2 (pro-IGF2) that is co-secreted with insulin and upregulates glucose-mediated insulin secretion. High serum preptin levels were described in conditions associated with insulin resistance, such as polycystic ovary syndrome and type 2 diabetes mellitus (T2M). Insulin and also IGF2 are known to be anabolic bone hormones. The "sweet bone" in T2M usually associates increased density, but altered microarchitecture. Therefore, preptin was proposed to be one of the energy regulatory hormones that positively impacts bone health. Experimental data demonstrate a beneficial impact of preptin upon the osteoblasts. Preptin also appears to regulate osteocalcin secretion, which in turn regulates insulin sensitivity. Preptin is greatly influenced by the glucose tolerance status and the level of physical exercise, both influencing the bone mass. Clinical studies describe low serum preptin concentrations in osteoporosis in both men and women, therefore opening the way towards considering preptin a potential bone anabolic therapy. The current review addresses the relationship between preptin and bone mass and metabolism in the experimental and clinical setting, also considering the effects of preptin on carbohydrate metabolism and the pancreatic-bone loop.
前ptin是一种由胰岛素样生长因子2（pro-IGF2）的E肽衍生而来的34个氨基酸的肽，它与胰岛素共同分泌，并上调葡萄糖介导的胰岛素分泌。在与胰岛素抵抗相关的疾病中，如多囊卵巢综合征和2型糖尿病（T2M），血清前ptin水平较高。胰岛素以及IGF2都是已知的合成代谢骨激素。T2M中的“甜蜜骨”通常与骨密度增加有关，但微观结构发生改变。因此，前ptin被认为是对骨骼健康有积极影响的能量调节激素之一。实验数据表明前ptin对成骨细胞有有益影响。前ptin似乎还能调节骨钙素的分泌，进而调节胰岛素敏感性。前ptin受葡萄糖耐量状态和体育锻炼水平的极大影响，二者均影响骨量。临床研究表明，男性和女性骨质疏松症患者的血清前ptin浓度较低，因此为将前ptin视为一种潜在的骨合成代谢疗法开辟了道路。本综述探讨了实验和临床环境中前ptin与骨量及代谢之间的关系，同时也考虑了前ptin对碳水化合物代谢和胰腺-骨循环的影响。
