Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Food Chem. 2013 Jun 1;138(2-3):1015-21. doi: 10.1016/j.foodchem.2012.09.147. Epub 2012 Nov 10.
Breast cancer is the most common malignancy among women and has an age-specific incidence profile. Over the last decade, many studies have demonstrated the anticancer activity of α-tocopherol, the main and most active form of natural vitamin E. α-Tocopherol-associated protein (TAP) was found to be one of the major α-tocopherol binding proteins in human serum and in liver, brain, and prostate tissues. In this study, we found that reduced TAP expression was significantly correlated with Her2/neu receptor expression, breast cancer stage and nodal stage in paired normal and cancerous breast tissue samples from 93 patients using real-time PCR analysis. A cell viability assay showed that α-tocopheryl succinate (α-TOS), a synthetic derivative of α-tocopherol, enhanced the cells' sensitivity to doxorubicin and resulted in a reduction in cell viability in breast cancers. Taken together, these data suggest that the use of vitamin E or its analogue as a dietary supplement may be beneficial for the treatment of cancer.
乳腺癌是女性中最常见的恶性肿瘤，具有特定年龄的发病率特征。在过去的十年中，许多研究表明α-生育酚（天然维生素 E 的主要和最活跃形式）具有抗癌活性。α-生育酚相关蛋白（TAP）被发现是人类血清以及肝脏、大脑和前列腺组织中主要的α-生育酚结合蛋白之一。在这项研究中，我们使用实时 PCR 分析发现，在 93 名患者的配对正常和癌组织样本中，TAP 表达减少与 Her2/neu 受体表达、乳腺癌分期和淋巴结分期显著相关。细胞活力测定表明，α-生育酚琥珀酸酯（α-TOS），一种α-生育酚的合成衍生物，增强了细胞对阿霉素的敏感性，并导致乳腺癌细胞活力降低。综上所述，这些数据表明，使用维生素 E 或其类似物作为膳食补充剂可能有益于癌症的治疗。
