低氧诱导因子蛋白将RB-E2F因子与血管生成联系起来。
HIF proteins connect the RB-E2F factors to angiogenesis.
作者信息
Bakker Walbert J, Weijts Bart G M W, Westendorp Bart, de Bruin Alain
机构信息
Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
出版信息
Transcription. 2013 Mar-Apr;4(2):62-6. doi: 10.4161/trns.23680. Epub 2013 Feb 14.
Recently, we showed that E2F7 and E2F8 (E2F7/8) are critical regulators of angiogenesis through transcriptional control of VEGFA in cooperation with HIF. (1) Here we investigate the existence of other novel putative angiogenic E2F7/8-HIF targets, and discuss the role of the RB-E2F pathway in regulating angiogenesis during embryonic and tumor development.
最近，我们发现E2F7和E2F8（E2F7/8）通过与缺氧诱导因子（HIF）协同转录调控血管内皮生长因子A（VEGFA），是血管生成的关键调节因子。（1）在此，我们研究其他新型假定的血管生成性E2F7/8-HIF靶点的存在情况，并讨论RB-E2F通路在胚胎发育和肿瘤发生过程中调节血管生成的作用。
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