Department of Ilmul Advia, Faculty of Unani Medicine, Jamia Hamdard, New Delhi-110062, India.
Z Naturforsch C J Biosci. 2012 Nov-Dec;67(11-12):580-6. doi: 10.1515/znc-2012-11-1208.
Phytochemical investigations of the methanolic extract of the fruits of Peucedanum grande C. B. Clarke (Apiaceae) led to the identification of three coumarins and a naphthyl labdanoate diarabinoside characterized as 5-hydroxy-6-isopranyl coumarin (1), 5,6-furanocoumarin (2), 7-methoxy-5,6-furanocoumarin (3), and labdanyl-3alpha-ol-18-(3'"-methoxy-2"'-naphthyl-oate)-3alpha-L-arabinofuranosyl-(2'-->1")-alpha-L-arabinofuranoside (4). The structures of these compounds were identified on the basis of spectral data analysis and chemical reactions. The methanolic extract and 4 showed nephroprotective activity against gentamicin-induced nephrotoxicity in Wistar rats.
从伞形科植物Peucedanum grande C. B. Clarke 的果实的甲醇提取物中进行的植物化学研究，鉴定出三种香豆素和一种萘基 labdanoate 二阿拉伯糖苷，分别为 5-羟基-6-异戊基香豆素（1）、5,6-呋喃香豆素（2）、7-甲氧基-5,6-呋喃香豆素（3）和 labdanyl-3alpha-ol-18-（3'"-甲氧基-2"'-萘基-oate）-3alpha-L-阿拉伯呋喃糖苷基-（2'-->1"）-alpha-L-阿拉伯呋喃糖苷（4）。这些化合物的结构是基于光谱数据分析和化学反应确定的。甲醇提取物和 4 对氨基糖苷诱导的 Wistar 大鼠肾毒性具有肾脏保护作用。
