在水相介质中，用 3-羟基-3-吲哚基氧化吲哚对醛进行不对称 α-烷基化。
Asymmetric α-alkylation of aldehydes with 3-hydroxy-3-indolylox-indoles in aqueous media.
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China.
出版信息
Org Biomol Chem. 2013 Mar 28;11(12):1933-7. doi: 10.1039/c3ob00045a. Epub 2013 Feb 18.
PMID:23417554
Abstract
Organocatalyzed asymmetric α-alkylation of aldehydes with 3-hydroxy-3-indolylox-indoles in aqueous media has been developed. The reactions proceeded efficiently in the presence of the MacMillan catalyst to give the desired products in good to excellent yields with moderate diastereoselectivities and excellent enantioselectivities.
摘要
在水相介质中，发展了有机催化的醛与 3-羟基-3-吲哚基氧化吲哚的不对称α-烷基化反应。在 MacMillan 催化剂的存在下，这些反应有效地进行，以中等至优异的收率、良好的非对映选择性和优异的对映选择性得到了所需的产物。
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