Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark; Endocrine Research Unit, Mayo Clinic, Rochester, MN, USA.
Obesity (Silver Spring). 2013 Sep;21(9):1836-42. doi: 10.1002/oby.20322. Epub 2013 May 29.
Obesity, insulin resistance, and diabetes disproportionately affect African-American (AA) women. Abnormal adipose tissue free fatty acid (FFA) release is associated with these conditions. Resting energy expenditure (REE) and sex predict FFA release in Caucasians, but whether this is true in AA is unknown. The sex-specific relationships between FFA release, REE, and race was compared.
100 adults (47% AA, 50% male, age 32 ± 8 years [mean ± SD]) from three different centers underwent duplicate measures of FFA release ([U-13C] palmitate) and REE (indirect calorimetry). Body composition was determined by DXA and abdominal imaging.
AA participants had lower REE, but similar FFA concentrations and flux compared with Caucasian participants. The significant predictors of palmitate release were REE, sex, and race. REE and FFA flux were correlated in both sexes and both races. In a multiple linear regression analysis with palmitate flux as the dependent variable and REE, sex, race, total fat mass, fat-free mass, and insulin as independent variables, REE was the only independent predictor of FFA release in men. Both REE and race predicted palmitate flux in women.
FFA flux is related to REE, but the relationship differs in AA and Caucasian women.
肥胖、胰岛素抵抗和糖尿病在非裔美国女性中发病率较高。异常的脂肪组织游离脂肪酸（FFA）释放与这些情况有关。静息能量消耗（REE）和性别可预测白种人的 FFA 释放，但这在非裔美国人中是否成立尚不清楚。本研究比较了 FFA 释放、REE 和种族在性别特异性方面的关系。
来自三个不同中心的 100 名成年人（47%为非裔美国人，50%为男性，年龄 32 ± 8 岁[均值 ± 标准差]）进行了两次 FFA 释放（[U-13C]棕榈酸）和 REE（间接测热法）的重复测量。身体成分通过 DXA 和腹部成像确定。
与白种人参与者相比，非裔美国人参与者的 REE 较低，但 FFA 浓度和通量相似。棕榈酸释放的显著预测因子是 REE、性别和种族。REE 和 FFA 通量在两性和两个种族中均相关。在以棕榈酸通量为因变量，REE、性别、种族、总脂肪量、去脂体重和胰岛素为自变量的多元线性回归分析中，REE 是男性 FFA 释放的唯一独立预测因子。REE 和种族均能预测女性的棕榈酸通量。
FFA 通量与 REE 有关，但在非裔美国人和白种女性中，这种关系不同。
