实验性脑缺血中碘安非他明再分布的放射自显影分析

Autoradiographic analysis of iodoamphetamine redistribution in experimental brain ischemia.

作者信息

Matsuda H, Tsuji S, Oba H, Shiba K, Terada H, Kinuya K, Mori H, Sumiya H, Hisada K

机构信息

Department of Nuclear Medicine, School of Medicine, Kanazawa University, Japan.

出版信息

J Nucl Med. 1990 May;31(5):660-7.

PMID:2341902

Abstract

The pathophysiologic significance of iodoamphetamine (IMP) redistribution was analyzed using a double radionuclide autoradiography technique in experimental brain ischemia in the rat. Within 4 hr after unilateral arterial occlusion, IMP almost completely redistributed at 150 min postinjection in the affected areas. At 2 min postinjection, both a remarkable decrease of IMP accumulation and histopathologic change of diminished staining were observed in these areas. The redistribution amplitude was higher in the affected hemisphere, especially in the regions surrounding the ischemic core than in the unaffected hemisphere. These findings were consistent with computer simulation studies of the time course of brain activity based on the standard diffusible tracer model. The results suggest that IMP redistribution in the ischemic area is due to differences of the temporal changes of the brain activity between the unaffected and affected areas and that it is a "physical" phenomenon (only flow related) rather than a "biologic" one.

摘要

采用双放射性核素放射自显影技术，分析了大鼠实验性脑缺血中碘安非他明（IMP）再分布的病理生理意义。在单侧动脉闭塞后4小时内，IMP在注射后150分钟时在受影响区域几乎完全再分布。注射后2分钟，在这些区域观察到IMP积累显著减少以及染色减弱的组织病理学变化。受影响半球的再分布幅度更高，尤其是缺血核心周围区域比未受影响半球更高。这些发现与基于标准可扩散示踪剂模型的脑活动时间进程的计算机模拟研究一致。结果表明，缺血区域的IMP再分布是由于未受影响区域和受影响区域之间脑活动时间变化的差异，并且它是一种“物理”现象（仅与血流有关）而非“生物学”现象。