The distribution of N-isopropyl-p-iodoamphetamine in temporary ischemic brain of the mongolian gerbil.

We studied the distribution of N-isopropyl-p-[131I]-iodoamphetamine (IMP) in the ischemic brain of 44 mongolian gerbils. The right common carotid artery was temporarily occluded by a clip and recirculated 3 h later. After given time intervals, 50 microCi of IMP was injected into 18 gerbils which had symptoms. One min after injection (or 10 min, 1 h, or 6 h after injection in other gerbils), each gerbil was killed and autoradiography was performed. IMP activity in various parts of the brain was calculated as %Dose/g from each autoradiogram. At one min after recirculation, partial no flow phenomenon was observed in the right cerebral hemisphere. From 10 min to 24 h after recirculation, a high uptake region was observed partially in the right cerebral hemisphere and thalamus. The high activity disappeared rapidly 10 min after injection. It seemed that this high uptake indicated luxury perfusion at the location of severe tissue damage. In the left side, the low perfusion recovered to an almost normal value at one to three days after recirculation. These results suggested the possibility that IMP could demonstrate luxury perfusion and diaschisis.