Karlsen S J, Smevik B, Stenstrøm J, Berg K J
Institute of Surgical Research, National Hospital, University of Oslo, Norway.
J Urol. 1990 Jun;143(6):1280-3. doi: 10.1016/s0022-5347(17)40255-2.
Nine anesthetized dogs were studied for four to five hours after administration of extracorporeal shock waves to one kidney, the contralateral organ serving as control. Urinary excretion of electrolytes, N-acetyl-beta-glucosaminidase (NAG) and kallikrein, clearances of creatinine, inulin and para-amino-hippuric acid (PAH), serum aldosterone level and plasma renin activity (PRA) were determined. On the exposed side there was a significant increase in urinary flow and urinary NAG excretion, and a significant fall in urinary osmolality. Effective renal plasma flow (ERPF) was reduced and glomerular filtration rate (GFR) unchanged, thus filtration fraction (FF) was increased. Extraction of PAH was significantly reduced compared with the control kidney. On the control side there was a significant increase in urinary flow and excretion of electrolytes, and a significant fall in urinary osmolality. GFR was increased and ERPF unchanged. FF therefore increased also on this side. The mean rise of PRA in the exposed kidney was higher than in the control kidney, the difference being not significant (p = 0.09). Our results may indicate a triggering of the renin-angiotensin system, and an effect on proximal tubular function following exposure of extracorporeal shock waves.
对9只麻醉犬进行研究，在对一侧肾脏施加体外冲击波后观察4至5小时，对侧肾脏作为对照。测定了电解质、N-乙酰-β-氨基葡萄糖苷酶（NAG）和激肽释放酶的尿排泄量，肌酐、菊粉和对氨基马尿酸（PAH）的清除率，血清醛固酮水平和血浆肾素活性（PRA）。在接受冲击波一侧，尿流量和尿NAG排泄量显著增加，尿渗透压显著降低。有效肾血浆流量（ERPF）降低，肾小球滤过率（GFR）不变，因此滤过分数（FF）增加。与对照肾脏相比，PAH的摄取显著减少。在对照侧，尿流量和电解质排泄量显著增加，尿渗透压显著降低。GFR增加，ERPF不变。因此，该侧的FF也增加。接受冲击波一侧的PRA平均升高高于对照侧，但差异不显著（p = 0.09）。我们的结果可能表明体外冲击波作用后肾素-血管紧张素系统被激活，并对近端肾小管功能产生影响。
