Faculty of Medicine, University of Geneva, Geneva, Switzerland.
J Low Genit Tract Dis. 2013 Jul;17(3):235-41. doi: 10.1097/LGT.0b013e31826b7b51.
The study aimed to assess acceptability and preference for self-collected human papillomavirus tests (self-HPV) compared with traditional physician-sampled Pap tests (physician sampling) in a low-resource country.
Women were recruited through a cervical cancer screening campaign conducted in Cameroon. Written and oral instructions were given to carry out an unsupervised self-HPV, followed by a physician-collected cervical sample for HPV testing and cytology. Subsequently the women were asked to answer a questionnaire.
A total of 243 women were prospectively enrolled in this study. Median age of participants was 39 years (range = 25-65 years). Acceptability score was higher for self-HPV (p < .001) compared with physician sampling. Preference was lower for self-HPV than physician sampling (29% vs 62%; p < .001). Most participants thought that physician sampling was more reliable than self-HPV (59% vs 1%; p < .001). Women who preferred physician sampling were significantly more likely to have low knowledge about cervical cancer and a low educational level.
Although most of the women were more comfortable and less embarrassed with the self-HPV, they did not trust the method and did prefer physician sampling. The study underlines the need not only to educate women about HPV, cervical cancer, and its prevention but also to reassure them about the accuracy of self-HPV.
本研究旨在评估在资源匮乏国家中，与传统医生采样巴氏涂片（physician sampling）相比，自我采集人乳头瘤病毒（HPV）检测（self-HPV）的可接受性和偏好性。
通过在喀麦隆开展的宫颈癌筛查活动招募女性。给予书面和口头指示，进行无人监督的自我 HPV 检测，随后由医生采集宫颈样本进行 HPV 检测和细胞学检查。随后，要求女性回答一份问卷。
本研究共前瞻性纳入 243 名女性。参与者的中位年龄为 39 岁（范围=25-65 岁）。与医生采样相比，自我 HPV 的接受度评分更高（p<0.001）。与医生采样相比，自我 HPV 的偏好度较低（29% vs 62%；p<0.001）。大多数参与者认为医生采样比自我 HPV 更可靠（59% vs 1%；p<0.001）。偏好医生采样的女性明显对宫颈癌的了解较少，受教育程度较低。
尽管大多数女性对自我 HPV 更舒适、更不尴尬，但她们并不信任这种方法，更倾向于医生采样。该研究强调，不仅需要教育女性了解 HPV、宫颈癌及其预防，还需要让她们对自我 HPV 的准确性放心。
