Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA.
J Expo Sci Environ Epidemiol. 2013 May-Jun;23(3):275-80. doi: 10.1038/jes.2013.10. Epub 2013 Feb 20.
Ambient particulate matter (PM) has been shown to have short- and long-term effects on cardiorespiratory mortality and morbidity. Most of the risk is associated with fine PM (PM(2.5)); however, recent evidence suggests that desert dust outbreaks are major contributors to coarse PM (PM(10-2.5)) and may be associated with adverse health effects. The objective of this study was to investigate the risk of total, cardiovascular and respiratory mortality associated with PM concentrations during desert dust outbreaks. We used a time-series design to investigate the effects of PM(10) on total non-trauma, cardiovascular and respiratory daily mortality in Cyprus, between 1 January 2004 and 31 December 2007. Separate PM(10) effects for non-dust and dust days were fit in generalized additive Poisson models. We found a 2.43% (95% CI: 0.53, 4.37) increase in daily cardiovascular mortality associated with each 10-μg/m(3) increase in PM(10) concentrations on dust days. Associations for total (0.13% increase, 95% CI: -1.03, 1.30) and respiratory mortality (0.79% decrease, 95% CI: -4.69, 3.28) on dust days and all PM(10) and mortality associations on non-dust days were not significant. Although further study of the exact nature of effects across different affected regions during these events is needed, this study suggests adverse cardiovascular effects associated with desert dust events.
环境颗粒物(PM)已被证明对心肺疾病的死亡率和发病率具有短期和长期影响。大多数风险与细颗粒物(PM2.5)有关;然而,最近的证据表明,沙尘暴是粗颗粒物(PM10-2.5)的主要来源,并且可能与不良健康影响有关。本研究的目的是调查沙尘暴期间 PM 浓度与总死亡率、心血管疾病死亡率和呼吸系统死亡率相关的风险。我们使用时间序列设计来研究 2004 年 1 月 1 日至 2007 年 12 月 31 日期间在塞浦路斯,PM10 对总非创伤性、心血管疾病和呼吸系统每日死亡率的影响。在广义加性泊松模型中分别拟合了 PM10 在非沙尘日和沙尘日对非创伤性、心血管疾病和呼吸系统的影响。我们发现,在沙尘日,PM10 浓度每增加 10μg/m3,与心血管疾病每日死亡率相关的风险增加 2.43%(95%CI:0.53,4.37)。总死亡率(增加 0.13%,95%CI:-1.03,1.30)和呼吸系统死亡率(降低 0.79%,95%CI:-4.69,3.28)的关联在沙尘日和非沙尘日均不显著。尽管需要进一步研究在这些事件中不同受影响地区的影响的确切性质,但本研究表明与沙尘暴事件相关的不良心血管影响。