X 射线触发纳米药物载体中阿霉素的释放用于癌症治疗。
X-ray triggered release of doxorubicin from nanoparticle drug carriers for cancer therapy.
机构信息
Department of Chemistry, University of California, One Shields Ave., Davis, CA 95616, USA.
出版信息
Chem Commun (Camb). 2013 Mar 28;49(25):2545-7. doi: 10.1039/c3cc38100e.
PMID:23423224
Abstract
Enhanced cellular toxicity was observed using X-ray irradiated nanoparticle drug carriers (NDC) consisting of doxorubicin (DOX) conjugated to DNA strands attached to the surface of gold nanoparticles. Kinetic studies showed that X-rays, acting as a triggering modality, generated reactive oxygen species to break DNA strands and release DOX.
摘要
使用 X 射线辐照的纳米颗粒药物载体（NDC）观察到增强的细胞毒性，该载体由连接到金纳米颗粒表面的 DNA 链共轭的阿霉素（DOX）组成。动力学研究表明，X 射线作为触发方式产生活性氧物质来破坏 DNA 链并释放 DOX。
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