Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Via Giustiniani 2, 35128 Padua, Italy.
Eur Heart J Cardiovasc Imaging. 2013 Nov;14(11):1106-14. doi: 10.1093/ehjci/jet024. Epub 2013 Feb 19.
Right atrial (RA) size predicts the outcome in some pathological conditions but reference values for RA volumes and myocardial function remain to be defined. Thus, we used two-dimensional speckle-tracking echocardiography (2D-STE) and three-dimensional echocardiography (3DE) to define normative reference values of RA volumes and function.
Two hundreds healthy volunteers (43 ± 15 years, range 18-75; 44% men) underwent two-dimensional echocardiography (2DE) to obtain RA volumes and longitudinal strain (LS) of RA wall using 2D-STE, and 3DE to measure maximal (Vmax), minimal, and preA volumes to calculate total, passive, and active emptying volumes (TotEV, PassEV, and ActEV) and emptying fractions (TotEF, PassEF, and ActEF). Three-dimensional echocardiography volumes (Vmax, 52 ± 15 mL vs. 41 ± 14 mL), EVs (TotEV, 33 ± 10 mL vs. 24 ± 9 mL), and EFs (TotEF, 63 ± 9 vs. 58 ± 9%) were larger than 2DE ones (all P < 0.0001). Indexed 3D volumes were significantly larger in men than in women. RA TotEF correlated with total LS (r = 0.24, P = 0.025) and PassEF with positive LS (LSpos; r = 0.34, P < 0.0001). Ageing was associated with a decrease in passive (LSpos, r = -041; PassEV, r = -0.26; PassEF, r = -0.38; all P < 0.0001) and an increase in active RA function (negative LS, r = 0.34; ActEV, r = 0.25; all P < 0.0001; and ActEF, r = 0.15; P = 0.035) in order to maintain TotEV (r = -0.14, P = 0.05).
Our study provides normative values for RA volumes and function measured by 3DE and 2D-STE in a relatively large cohort of healthy subjects with a wide age range. These data will help clinicians to identify RA remodelling and dysfunction.
右心房（RA）大小可预测某些病理情况下的结局，但 RA 容积和心肌功能的参考值仍有待确定。因此，我们使用二维斑点追踪超声心动图（2D-STE）和三维超声心动图（3DE）来定义 RA 容积和功能的正常参考值。
200 名健康志愿者（43±15 岁，18-75 岁；44%为男性）接受二维超声心动图（2DE）检查，使用 2D-STE 测量 RA 壁的纵向应变（LS）和 RA 容积，接受 3DE 检查以测量最大（Vmax）、最小和前 A 容积，以计算总、被动和主动排空容积（TotEV、PassEV 和 ActEV）和排空分数（TotEF、PassEF 和 ActEF）。3DE 测量的容积（Vmax，52±15ml 比 41±14ml）、EVs（TotEV，33±10ml 比 24±9ml）和 EFs（TotEF，63±9% 比 58±9%）均大于 2DE 测量值（均 P<0.0001）。男性的 3D 指数容积明显大于女性。RA TotEF 与总 LS（r=0.24，P=0.025）相关，PassEF 与正 LS（LSpos；r=0.34，P<0.0001）相关。随年龄增长，被动排空（LSpos，r=-0.41；PassEV，r=-0.26；PassEF，r=-0.38；均 P<0.0001）和主动 RA 功能（负 LS，r=0.34；ActEV，r=0.25；均 P<0.0001；和 ActEF，r=0.15；P=0.035）均减少，以维持 TotEV（r=-0.14，P=0.05）。
本研究在一个相对较大的、年龄范围较宽的健康受试者队列中，提供了 3DE 和 2D-STE 测量的 RA 容积和功能的正常值。这些数据将有助于临床医生识别 RA 重构和功能障碍。
