Guy J, Mancuso A, Quisling R G, Beck R, Moster M
Department of Ophthalmology, University of Florida, Gainesville 32610-0284.
Ophthalmology. 1990 May;97(5):592-9; discussion 599-600.
Magnetic resonance imaging (MRI), after intravenous administration of the paramagnetic agent gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA), showed enhancement of the optic nerve in 7 of 13 patients with acute optic neuritis. Four of these patients had Gd-DTPA enhancement of the intracranial optic nerve and two had involvement of the optic nerve at the orbital apex, ipsilateral to the eye with visual loss. Gadolinium-DTPA enhancement of both intracranial optic nerves was seen in one of two patients with bilateral retrobulbar neuritis. Two patients with acute radiation-induced optic neuropathy also had Gd-DTPA enhancement of the intracranial optic nerve. The authors recommend MRI with Gd-DTPA as the neuro-diagnostic procedure of choice for visualization of increased permeability of the blood-brain barrier in acute optic neuritis and radiation-induced optic neuropathy.
静脉注射顺磁性造影剂钆-二乙烯三胺五乙酸（Gd-DTPA）后进行的磁共振成像（MRI）显示，13例急性视神经炎患者中有7例视神经出现强化。其中4例患者颅内视神经有Gd-DTPA强化，2例患者眼眶尖部视神经受累，与视力丧失的患眼同侧。2例双侧球后视神经炎患者中有1例双侧颅内视神经均有Gd-DTPA强化。2例急性放射性视神经病变患者颅内视神经也有Gd-DTPA强化。作者推荐使用Gd-DTPA进行MRI检查，作为诊断急性视神经炎和放射性视神经病变时血脑屏障通透性增加的首选神经诊断方法。
