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1
Surveillance without chemotherapy in a woman with recurrent molar pregnancy.复发性葡萄胎女性无需化疗的监测
BMJ Case Rep. 2013 Feb 20;2013:bcr2012008128. doi: 10.1136/bcr-2012-008128.
2
Persistent trophoblast disease following partial molar pregnancy.部分性葡萄胎后持续性滋养细胞疾病
Aust N Z J Obstet Gynaecol. 2006 Apr;46(2):119-23. doi: 10.1111/j.1479-828X.2006.00539.x.
3
Persistence of gestational trophoblastic disease for longer than 1 year following evacuation of hydatidiform mole.葡萄胎排空后妊娠滋养细胞疾病持续超过1年。
Obstet Gynecol. 1993 May;81(5 ( Pt 2)):888-90.
4
Gestational trophoblastic diseases - clinical guidelines for diagnosis, treatment, follow-up, and counselling.妊娠滋养细胞疾病——诊断、治疗、随访及咨询临床指南
Dan Med J. 2015 Nov;62(11):A5082.
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Guidelines following hydatidiform mole: a reappraisal.葡萄胎后的指南：重新评估
Aust N Z J Obstet Gynaecol. 2006 Apr;46(2):112-8. doi: 10.1111/j.1479-828X.2006.00538.x.
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Recurrent partial hydatidiform mole: a report of a patient with three consecutive molar pregnancies.复发性部分性葡萄胎：一例连续三次妊娠为葡萄胎患者的报告。
Int J Gynecol Cancer. 2006 Mar-Apr;16(2):940-3. doi: 10.1111/j.1525-1438.2006.00232.x.
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Human chorionic gonadotropin follow-up in patients with molar pregnancy: a time for reevaluation.葡萄胎患者的人绒毛膜促性腺激素随访：重新评估的时机
Obstet Gynecol. 2003 Apr;101(4):732-6. doi: 10.1016/s0029-7844(03)00009-7.
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Clinical features of early-stage nonhydropic mole for diagnosis of persistent trophoblastic disease.早期非水肿性葡萄胎的临床特征用于诊断持续性滋养细胞疾病。
Obstet Gynecol. 2011 Oct;118(4):847-53. doi: 10.1097/AOG.0b013e31822adb8a.
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An unusual clinical course after mole evacuation: a case report.葡萄胎排空后的异常临床病程：一例报告
Nagoya J Med Sci. 1997 Mar;60(1-2):49-52.
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Low risk of relapse after achieving undetectable HCG levels in women with complete molar pregnancy.完全性葡萄胎妊娠女性人绒毛膜促性腺激素（HCG）水平降至检测不到后复发风险低。
Obstet Gynecol. 2004 Sep;104(3):551-4. doi: 10.1097/01.AOG.0000136099.21216.45.

本文引用的文献

1
Chemotherapy and human chorionic gonadotropin concentrations 6 months after uterine evacuation of molar pregnancy: a retrospective cohort study.化疗和人绒毛膜促性腺激素浓度在葡萄胎刮宫术后 6 个月：一项回顾性队列研究。
Lancet. 2012 Jan 14;379(9811):130-5. doi: 10.1016/S0140-6736(11)61265-8. Epub 2011 Nov 28.
2
Hyperglycosylated hCG in the management of quiescent and chemorefractory gestational trophoblastic diseases.高糖基化人绒毛膜促性腺激素在静止期和化疗难治性妊娠滋养细胞疾病管理中的应用
Gynecol Oncol. 2010 Jan;116(1):3-9. doi: 10.1016/j.ygyno.2009.09.028. Epub 2009 Oct 12.
3
Prognostic markers and long-term outcome of placental-site trophoblastic tumours: a retrospective observational study.胎盘部位滋养细胞肿瘤的预后标志物及长期结局：一项回顾性观察研究
Lancet. 2009 Jul 4;374(9683):48-55. doi: 10.1016/S0140-6736(09)60618-8. Epub 2009 Jun 22.
4
A conservative approach in persistent low-level elevation of serum beta-human chorionic gonadotropin following chemotherapy for gestational trophoblastic neoplasia.妊娠滋养细胞肿瘤化疗后血清β-人绒毛膜促性腺激素持续低水平升高时的保守治疗方法。
J Reprod Med. 2009 May;54(5):288-90.
5
Management and outcome of healthy women with a persistently elevated beta-hCG.β-人绒毛膜促性腺激素持续升高的健康女性的管理与结局
Gynecol Oncol. 2007 Jul;106(1):35-43. doi: 10.1016/j.ygyno.2007.01.053. Epub 2007 May 4.
6
Persistent gestational trophoblastic neoplasia after partial hydatidiform mole incidence and outcome.部分性葡萄胎后持续性妊娠滋养细胞肿瘤的发生率及结局
J Reprod Med. 2006 Oct;51(10):764-6.
7
The significance of the time interval between antecedent pregnancy and diagnosis of high-risk gestational trophoblastic tumours.前次妊娠与高危妊娠滋养细胞肿瘤诊断之间时间间隔的意义。
Br J Cancer. 2006 Nov 6;95(9):1145-7. doi: 10.1038/sj.bjc.6603416. Epub 2006 Oct 10.
8
Recurrent partial hydatidiform mole: a report of a patient with three consecutive molar pregnancies.复发性部分性葡萄胎：一例连续三次妊娠为葡萄胎患者的报告。
Int J Gynecol Cancer. 2006 Mar-Apr;16(2):940-3. doi: 10.1111/j.1525-1438.2006.00232.x.
9
Placental site trophoblastic tumour arising from a partial hydatidiform mole.源自部分性葡萄胎的胎盘部位滋养细胞肿瘤。
Lancet. 2005;366(9486):688. doi: 10.1016/S0140-6736(05)67143-7.
10
Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy.完全性或部分性葡萄胎妊娠后复发性葡萄胎的风险及后续妊娠结局
BJOG. 2003 Jan;110(1):22-6.

复发性葡萄胎女性无需化疗的监测

Surveillance without chemotherapy in a woman with recurrent molar pregnancy.

作者信息

Bagga Rashmi, Siwatch Sujata, Srinivasan Radhika, Dhaliwal Lakhbir Kaur

机构信息

Department of Obstetrics & Gynecology, PGIMER, Chandigarh, India.

出版信息

BMJ Case Rep. 2013 Feb 20;2013:bcr2012008128. doi: 10.1136/bcr-2012-008128.

DOI:10.1136/bcr-2012-008128
PMID:23429019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3603678/
Abstract

A 27-year-old fouth gravida patient with previous two partial molar pregnancies and one missed abortion underwent a suction evacuation for partial molar pregnancy at 9 weeks of gestation. She was followed up with serum HCG values. Though the HCG level reduced from a pre-evacuation value of 1 40 223-31 157 mIU/ml 1 week post procedure, the levels continued to be positive in low titres 6 months after suction evacuation. The management options were discussed with the patient and a decision was taken to continue surveillance with serial HCG titres. HCG levels normalised after 11 months without the need for chemotherapy.

摘要

一名27岁、孕4产的患者，既往有两次部分性葡萄胎妊娠史及一次稽留流产史，在妊娠9周时因部分性葡萄胎行负压吸宫术。术后对其进行血清人绒毛膜促性腺激素（HCG）值随访。虽然术后1周HCG水平从吸宫术前的140223降至31157mIU/ml，但吸宫术后6个月其水平仍呈低滴度阳性。与患者讨论了处理方案，决定继续通过连续检测HCG滴度进行监测。11个月后HCG水平恢复正常，无需化疗。