β-酪蛋白吗啡对大鼠新生幼崽睡眠的影响。

Effect of beta-casomorphin on neonatal sleep in rats.

作者信息

Taira T, Hilakivi L A, Aalto J, Hilakivi I

机构信息

University of Helsinki, Department of Physiology, Finland.

出版信息

Peptides. 1990 Jan-Feb;11(1):1-4. doi: 10.1016/0196-9781(90)90101-a.

DOI:10.1016/0196-9781(90)90101-a

PMID:2342985

Abstract

The effects of bovine beta-casomorphin(1-7) (Tyr-Pro-Phe-Pro-Gly-Pro-Ile) on neonatal sleep in rats were studied. The pups received intraperitoneal injections of beta-casomorphin(1-7) (1 mg, 5 mg, 10 mg, 50 mg, or 100 mg/kg) or a corresponding volume of sodium chloride. In any of the doses used, beta-casomorphin(1-7) had no effect on waking. Only 100 mg/kg caused significant changes in sleep: the percentage of quiet state of the total recording time (TRT) increased and the percentage of active sleep decreased. Beta-casomorphin(1-7) did not cause significant respiratory depression. Naloxone pretreatment (1 mg/kg IP) reversed the effects of beta-casomorphin(1-7) on sleep, a finding which suggests that opiate mu-receptors are involved in mediating the sleep effects of beta-casomorphin.

摘要

研究了牛β-酪蛋白吗啡（1-7）（酪氨酸-脯氨酸-苯丙氨酸-脯氨酸-甘氨酸-脯氨酸-异亮氨酸）对新生大鼠睡眠的影响。幼崽接受腹腔注射β-酪蛋白吗啡（1-7）（1毫克、5毫克、10毫克、50毫克或100毫克/千克）或相应体积的氯化钠。在所使用的任何剂量下，β-酪蛋白吗啡（1-7）对觉醒均无影响。只有100毫克/千克引起睡眠的显著变化：总记录时间（TRT）中安静状态的百分比增加，活跃睡眠的百分比降低。β-酪蛋白吗啡（1-7）未引起显著的呼吸抑制。纳洛酮预处理（1毫克/千克腹腔注射）逆转了β-酪蛋白吗啡（1-7）对睡眠的影响，这一发现表明阿片μ受体参与介导β-酪蛋白吗啡的睡眠效应。