[去酪氨酸-D-苯丙氨酸3]β-酪蛋白吗啡（2-5）对大鼠睡眠模式的影响。

Effects of [des-Tyr-D-Phe3]beta-casomorphin (2-5) on sleep pattern in rats.

作者信息

Schulz S, Diedrich M, Wetzel W, Matthies H

机构信息

Institute of Pharmacology and Toxicology, Medical Academy, Magdeburg, Germany.

出版信息

Peptides. 1991 Jul-Aug;12(4):893-6. doi: 10.1016/0196-9781(91)90153-g.

DOI:10.1016/0196-9781(91)90153-g

PMID:1788151

Abstract

The effects of the antidepressant-like acting peptide [des-Tyr-D-Phe3]beta-casomorphin(2-5) (Pro-D-Phe-Pro-Gly, BCH-325) on sleep were studied in rats. The rats received subcutaneous injections of BCH-325 in acute experiments (doses: 4, 20, 100, 500 and 2500 nmol/kg) and in a 10-day chronic experiment (50 nmol/kg/day). Acute administration of 20 and 100 nmol/kg enhanced wakefulness, 500 and 2500 nmol/kg enhanced paradoxical sleep, and 4 nmol/kg had no effect. Chronic administration resulted in an increase of paradoxical sleep during the first 5 days of drug treatment. Thus the sleep effects of BCH-325 differ from those of typical antidepressants and other psychotropic drugs.

摘要

研究了具有抗抑郁样作用的肽[去酪氨酸-D-苯丙氨酸3]β-酪蛋白吗啡(2-5)(脯氨酸-D-苯丙氨酸-脯氨酸-甘氨酸，BCH-325)对大鼠睡眠的影响。在急性实验中（剂量：4、20、100、500和2500 nmol/kg）以及在为期10天的慢性实验中（50 nmol/kg/天），给大鼠皮下注射BCH-325。急性给予20和100 nmol/kg可增强觉醒，500和2500 nmol/kg可增强异相睡眠，4 nmol/kg无作用。慢性给药导致在药物治疗的前5天异相睡眠增加。因此，BCH-325的睡眠效应不同于典型抗抑郁药和其他精神药物。