Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
Eur J Heart Fail. 2013 Jul;15(7):717-23. doi: 10.1093/eurjhf/hft028. Epub 2013 Feb 20.
The prevalence of heart failure (HF) increases with age. While clinical trials suggest that contemporary evidence-based HF therapies have reduced morbidity and mortality, these trials largely excluded the elderly. Questions remain regarding the clinical characteristics of elderly HF patients and the impact of contemporary therapies on their outcomes. This review presents the epidemiology of HF in the elderly and summarizes the data on the pathophysiology of the ageing heart. The clinical characteristics, treatment patterns, and outcomes of elderly HF patients are explored. Finally, the main gaps regarding HF therapies in the elderly and the opportunities for future trials are highlighted.
心力衰竭（HF）的患病率随年龄增长而增加。虽然临床试验表明，当代循证 HF 治疗方法降低了发病率和死亡率，但这些试验主要排除了老年人。关于老年 HF 患者的临床特征以及当代治疗方法对其结局的影响，仍存在疑问。本综述介绍了老年 HF 的流行病学，并总结了关于衰老心脏病理生理学的数据。探讨了老年 HF 患者的临床特征、治疗模式和结局。最后，强调了老年 HF 治疗方面的主要空白以及未来试验的机会。
