Division of Cardiology, Department of Medicine, Walter MacKenzie Health Sciences Centre, University of Alberta and Hospitals, Edmonton, AB, Canada.
Heart Fail Rev. 2012 Sep;17(4-5):531-44. doi: 10.1007/s10741-012-9299-x.
Significant growth in the elderly population (age ≥ 65 years) with heart failure (HF) has taken place in developed countries and is occurring in most developing countries. Projections from population studies in the United States, Europe and other developed countries suggest that this trend will very likely continue and tax healthcare systems worldwide. Prevention of HF in the elderly should be a healthcare priority. Preventive strategies are urgently needed to combat the rising burden of HF and related complications in elderly men and women of tomorrow. The strategies should address the aging continuum and the cumulative impact of lifelong exposure to cardiovascular (CV) risk factors and consider the associated pathobiology and pathophysiology of aging for optimal impact. Besides implementation of conventional primary and secondary prevention measures in young and older adults, more emphasis should be placed on education about the role of exposure to adverse CV risk factors from early childhood in the march to HF. More research is also needed to identify optimal HF therapies for different aging subgroups ranging from young adults to the elderly and very old based on understanding of pathobiology and pathophysiology.
老年人口(年龄≥65 岁)的显著增长在发达国家发生,并且在大多数发展中国家也正在发生。来自美国、欧洲和其他发达国家的人口研究预测,这种趋势很可能会持续下去,并给全球的医疗保健系统带来负担。预防老年人心力衰竭应该成为医疗保健的重点。迫切需要预防策略来应对未来老年男性和女性心力衰竭和相关并发症的负担不断增加。这些策略应该针对衰老的连续体和终身暴露于心血管(CV)危险因素的累积影响,并考虑衰老的相关病理生物学和病理生理学,以实现最佳效果。除了在年轻人和老年人中实施常规的一级和二级预防措施外,还应更加重视对从儿童早期开始接触不良 CV 危险因素在心力衰竭发展过程中作用的教育。还需要更多的研究来根据病理生物学和病理生理学的理解,为从年轻人到老年人和非常老年人的不同衰老亚组确定最佳的心力衰竭治疗方法。