18-FDG-PET 评估大动脉炎疾病活动度的荟萃分析。
18-FDG-PET in assessing disease activity in Takayasu arteritis: a meta-analysis.
机构信息
Department of Cardiology, Chinese Academy of Medical Sciences and Peking Union Medical College & Fuwai Hospital, Department of Cardiology, National Center for Cardiovascular Diseases, Beijing, China.
出版信息
Clin Exp Rheumatol. 2013 Jan-Feb;31(1 Suppl 75):S22-7. Epub 2013 Feb 25.
OBJECTIVES
To assess the diagnosis value of 18-FDG-PET in estimating disease activity in Takayasu arteritis.
METHODS
A complete search of PubMed, EMBASE and The Cochrane Library was finished to July 25, 2012. Sensitivity and specificity as well as pooled estimates of positive and negative likelihood ratios (PLR and NLR) were calculated by Meta-Disc. We also calculated the area under the sROC curve (AUC) and the Q* index.
RESULTS
The meta-analysis was finished with 6 study retrieved from the database search. The pooled sensitivity, and specificity with 95% confidence interval were 70.1% (95% CI, 58.6-80.0) and 77.2% (95% CI, 64.2-87.3). The PLR and NLR were 2.313 (95% CI 1.108-4.829) and 0.341 (95% CI 0.142-0.824). The AUC was 0.805(±0.084) and Q* index was 0.7402 (±0.0739).
CONCLUSIONS
18-FDG-PET had moderate diagnosis value in assessing TA activity. It may add additional value to the current diagnosis methods.
目的
评估 18-FDG-PET 在评估大动脉炎（Takayasu arteritis，TA）疾病活动度中的诊断价值。
方法
对 PubMed、EMBASE 和 The Cochrane Library 进行了全面检索，检索时间截至 2012 年 7 月 25 日。采用 Meta-Disc 计算敏感度、特异度和阳性及阴性似然比（positive and negative likelihood ratios，PLR 和 NLR）的合并估计值，并计算曲线下面积（area under the sROC curve，AUC）和 Q*指数。
结果
从数据库检索中获得 6 项研究进行了荟萃分析。合并的敏感度和特异度及其 95%置信区间分别为 70.1%（95%CI，58.6-80.0）和 77.2%（95%CI，64.2-87.3）。阳性和阴性似然比分别为 2.313（95%CI，1.108-4.829）和 0.341（95%CI，0.142-0.824）。AUC 为 0.805（±0.084），Q*指数为 0.7402（±0.0739）。
结论
18-FDG-PET 在评估 TA 活动度方面具有中等诊断价值，它可能为当前的诊断方法提供额外的价值。
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