探究帕他霉素在抗生素、抗肿瘤和抗原生动物活性方面的功能多样性。
Probing functional diversity in pactamycin toward antibiotic, antitumor, and antiprotozoal activity.
机构信息
Department of Chemistry, Université de Montréal, Station Centre Ville, CP 6128, Montréal, Qc, Canada H3C 3J7.
出版信息
Bioorg Med Chem. 2013 Apr 1;21(7):1775-86. doi: 10.1016/j.bmc.2013.01.037. Epub 2013 Jan 31.
PMID:23434136
Abstract
A total of eight new analogs of pactamycin were prepared and tested alongside pactamycin and three of its natural congeners for antibacterial, anticancer, and antiprotozoal activities. The present study highlights the effects of changing the urea and aniline groups especially with regard to anticancer and antiprotozoal activities.
摘要
总共制备了 8 种新的 pactamycin 类似物，并与 pactamycin 及其三种天然同系物一起测试了它们的抗菌、抗癌和抗原生动物活性。本研究特别强调了改变脲和苯胺基团的影响，特别是在抗癌和抗原生动物活性方面。
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