Departamento de Investigación en Polímeros y Materiales-DIPM, Universidad de Sonora, Calle Rosales y Blvd, Luis Encinas s/n, Col. Centro, PO Box 130, Hermosillo Sonora 83000, Mexico.
Molecules. 2013 Jan 29;18(2):1762-74. doi: 10.3390/molecules18021762.
The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33-octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe₂PO and Fe₂PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe₂PO and Fe₂PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models.
环芳烷 2,9,25,32-四氧代-4,7,27,30-四（羧甲基）-1,4,7,10,24,27,30,33-八氮杂-17,40-二氧杂[10.1.10.1] 对环芳烷 (PO) 和 2,9,25,32-四氧代-4,7,27,30-四（羧甲基）-1,4,7,10,24,27,30,33-八氮杂-17,40-二氧杂[10.1.10.1] 对环芳烷 (PC) 与铁配位形成阳离子双核 Fe(III)Fe₂PO 和 Fe₂PC 配合物，分别。评估了它们的抗氧化能力、超氧化物歧化酶和过氧化物酶模拟活性以及它们对外周血单个核细胞 (PBMC) 的毒性。Fe₂PO 和 Fe₂PC 都是具有抗氧化能力的有趣仿生物，其抗氧化能力与抗坏血酸相似，可防止培养的 PBMC 死亡，有可能在疾病动物模型中具有生物活性和保护功能。
