Poison Control Center, Hospital Sainte Marguerite, 270 Boulevard Sainte Marguerite, 13009, Marseille, France.
J Med Toxicol. 2013 Jun;9(2):144-7. doi: 10.1007/s13181-012-0283-6.
Paraquat, a widely used herbicide in the world, has caused severe and fatal poisonings. Because of its high toxicity, the European Union withdrew paraquat from its market in July 2007. The purpose of this report is to describe cases of paraquat poisoning recorded at the Poison Control Center in Marseille over the 9-year period starting and ending 4.5 years before and after the paraquat ban. Data analysis showed that the most severe exposures were linked to ingestion. The fatality rate of deliberate consumption was near 50 % (34 suicide attempts and 15 deaths). Our data showed a marginal decline in total number of poisonings observed after the paraquat ban (38 vs 33 after the ban) mostly due to a decrease in the number of unintentional exposure (21 vs 16 after the ban). However, there was no apparent change in the number suicidal attempts using paraquat. Regarding geographical distribution, data showed that most poisonings in mainland France were unintentional, while poisonings in overseas French territories were mostly voluntary. Despite the European ban and the preventive measures, paraquat continues to contribute to severe and life-threatening poisonings in Southeastern and overseas France.
百草枯，一种在世界范围内广泛使用的除草剂，已导致严重和致命的中毒事件。由于其毒性很高，欧盟已于 2007 年 7 月将百草枯从市场上撤回。本报告的目的是描述在马赛中毒控制中心记录的百草枯中毒病例，这些病例发生在百草枯禁令实施前和实施后 4.5 年的 9 年期间内。数据分析表明，最严重的暴露与摄入有关。故意摄入的死亡率接近 50%（34 例自杀企图和 15 例死亡）。我们的数据显示，百草枯禁令实施后观察到的总中毒人数略有下降（禁令后为 38 例，而禁令前为 33 例），主要是由于非故意暴露的数量减少（禁令后为 21 例，而禁令前为 16 例）。然而，使用百草枯自杀的企图数量似乎没有明显变化。关于地域分布，数据显示，法国本土的大多数中毒事件是无意的，而海外法国领土的中毒事件大多是自愿的。尽管有欧洲禁令和预防措施，百草枯仍在法国东南部和海外导致严重和危及生命的中毒事件。
