• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

亚慢性染毒后水氯化副产物二氯乙酸盐和三氯乙酸盐混合物对小鼠吞噬作用的诱导激活。

The induction of phagocytic activation by mixtures of the water chlorination by-products, dichloroacetate- and trichloroacetate, in mice after subchronic exposure.

机构信息

College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Toledo, OH 43614-2598, USA.

出版信息

J Biochem Mol Toxicol. 2013 Apr;27(4):237-42. doi: 10.1002/jbt.21476. Epub 2013 Feb 21.

DOI:10.1002/jbt.21476
PMID:23436740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3646527/
Abstract

In this study, groups of B6C3F1 male mice were treated with dichloroacetate (DCA), trichloroacetate (TCA), and mixtures of the compounds (Mix I, II, and III) daily by gavage, for 13 weeks. The tested doses were 7.5, 15, and 30 mg DCA/kg/day and 12.5, 25, and 50 mg TCA/kg/day. The DCA: TCA ratios in Mix I, II, and III were 7.5:12.5, 15:25, and 30:50 mg/kg/day, respectively. Peritoneal lavage cells were collected at the end of the treatment period and assayed for the biomarkers of phagocytic activation, including superoxide anion and tumor necrosis factor-alpha production, and myeloperoxidase activity. The mixtures produced nonlinear effects on the biomarkers of phagocytic activation, with Mix I and II effects were found to be additive, but Mix III effects were found to be less than additive.

摘要

在这项研究中，B6C3F1 雄性小鼠经灌胃每日接受二氯乙酸（DCA）、三氯乙酸（TCA）和化合物混合物（混合物 I、II 和 III）处理，共 13 周。测试剂量分别为 DCA 7.5、15 和 30mg/kg/天和 TCA 12.5、25 和 50mg/kg/天。混合物 I、II 和 III 中 DCA:TCA 的比例分别为 7.5:12.5、15:25 和 30:50mg/kg/天。在治疗期末收集腹腔灌洗细胞，并测定吞噬细胞激活的生物标志物，包括超氧阴离子和肿瘤坏死因子-α的产生以及髓过氧化物酶活性。混合物对吞噬细胞激活的生物标志物产生非线性影响，混合物 I 和 II 的作用被发现是相加的，但混合物 III 的作用被发现小于相加。

相似文献

1
The induction of phagocytic activation by mixtures of the water chlorination by-products, dichloroacetate- and trichloroacetate, in mice after subchronic exposure.亚慢性染毒后水氯化副产物二氯乙酸盐和三氯乙酸盐混合物对小鼠吞噬作用的诱导激活。
J Biochem Mol Toxicol. 2013 Apr;27(4):237-42. doi: 10.1002/jbt.21476. Epub 2013 Feb 21.
2
The induction of tumor necrosis factor-alpha, superoxide anion, myeloperoxidase, and superoxide dismutase in the peritoneal lavage cells of mice after prolonged exposure to dichloroacetate and trichloroacetate.长时间接触二氯乙酸和三氯乙酸后，小鼠腹腔灌洗细胞中肿瘤坏死因子-α、超氧阴离子、髓过氧化物酶和超氧化物歧化酶的诱导。
J Biochem Mol Toxicol. 2010 Mar-Apr;24(2):136-44. doi: 10.1002/jbt.20322.
3
The effects of mixtures of dichloroacetate and trichloroacetate on induction of oxidative stress in livers of mice after subchronic exposure.二氯乙酸和三氯乙酸混合物对亚慢性染毒小鼠肝脏氧化应激诱导的影响。
J Toxicol Environ Health A. 2014;77(6):313-23. doi: 10.1080/15287394.2013.864576.
4
Dichloroacetate- and trichloroacetate-induced phagocytic activation and production of oxidative stress in the hepatic tissues of mice after acute exposure.急性暴露后二氯乙酸和三氯乙酸诱导小鼠肝组织中的吞噬细胞活化及氧化应激产生
J Biochem Mol Toxicol. 2008 Feb;22(1):27-34. doi: 10.1002/jbt.20210.
5
Interactions in the tumor-promoting activity of carbon tetrachloride, trichloroacetate, and dichloroacetate in the liver of male B6C3F1 mice.四氯化碳、三氯乙酸和二氯乙酸在雄性B6C3F1小鼠肝脏中促肿瘤活性的相互作用。
Toxicology. 2004 Jul 1;199(2-3):169-83. doi: 10.1016/j.tox.2004.02.018.
6
Do Antioxidant Enzymes and Glutathione Play Roles in the Induction of Hepatic Oxidative Stress in Mice upon Subchronic Exposure to Mixtures of Dichloroacetate and Trichloroacetate?在小鼠亚慢性暴露于二氯乙酸和三氯乙酸混合物后，抗氧化酶和谷胱甘肽是否在肝脏氧化应激的诱导中发挥作用？
Toxicol Environ Chem. 2014 Mar;96(3):482-490. doi: 10.1080/02772248.2014.947988.
7
Vitamin E restriction in the diet enhances phagocytic activation by dichloroacetate and trichloroacetate in mice.饮食中维生素 E 的限制增强了二氯乙酸和三氯乙酸对小鼠的吞噬激活作用。
Food Chem Toxicol. 2012 Mar;50(3-4):701-6. doi: 10.1016/j.fct.2011.11.055. Epub 2011 Dec 9.
8
Metabolism and lipoperoxidative activity of trichloroacetate and dichloroacetate in rats and mice.三氯乙酸和二氯乙酸在大鼠和小鼠体内的代谢及脂过氧化活性
Toxicol Appl Pharmacol. 1992 Aug;115(2):268-77. doi: 10.1016/0041-008x(92)90332-m.
9
Dichloroacetate- and trichloroacetate-induced oxidative stress in the hepatic tissues of mice after long-term exposure.长期暴露后，二氯乙酸盐和三氯乙酸盐在小鼠肝组织中诱导的氧化应激。
J Appl Toxicol. 2010 Jul;30(5):450-6. doi: 10.1002/jat.1516.
10
Effect of pre-treatment with dichloroacetic or trichloroacetic acid in drinking water on the pharmacokinetics of a subsequent challenge dose in B6C3F1 mice.饮用水中用二氯乙酸或三氯乙酸预处理对B6C3F1小鼠后续激发剂量药代动力学的影响。
Chem Biol Interact. 1999 Dec 15;123(3):239-53. doi: 10.1016/s0009-2797(99)00140-4.

引用本文的文献

1
The effects of mixtures of dichloroacetate and trichloroacetate on induction of oxidative stress in livers of mice after subchronic exposure.二氯乙酸和三氯乙酸混合物对亚慢性染毒小鼠肝脏氧化应激诱导的影响。
J Toxicol Environ Health A. 2014;77(6):313-23. doi: 10.1080/15287394.2013.864576.

本文引用的文献

1
Characterization of nonvolatile aqueous chlorination products of humic substances.腐殖质非挥发性水相氯化产物的表征
Environ Sci Technol. 1983 Mar 1;17(3):150-7. doi: 10.1021/es00109a006.
2
Dichloroacetate- and Trichloroacetate-Induced Modulation of Superoxide Dismutase, Catalase, and Glutathione Peroxidase Activities and Glutathione Level in the livers of Mice after Subacute and Subchronic exposure.亚急性和亚慢性暴露后二氯乙酸和三氯乙酸对小鼠肝脏中超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶活性及谷胱甘肽水平的影响
Toxicol Environ Chem. 2011 Feb;93(2):332-344. doi: 10.1080/02772248.2010.509602.
3
The induction of tumor necrosis factor-alpha, superoxide anion, myeloperoxidase, and superoxide dismutase in the peritoneal lavage cells of mice after prolonged exposure to dichloroacetate and trichloroacetate.长时间接触二氯乙酸和三氯乙酸后，小鼠腹腔灌洗细胞中肿瘤坏死因子-α、超氧阴离子、髓过氧化物酶和超氧化物歧化酶的诱导。
J Biochem Mol Toxicol. 2010 Mar-Apr;24(2):136-44. doi: 10.1002/jbt.20322.
4
Dichloroacetate- and trichloroacetate-induced oxidative stress in the hepatic tissues of mice after long-term exposure.长期暴露后，二氯乙酸盐和三氯乙酸盐在小鼠肝组织中诱导的氧化应激。
J Appl Toxicol. 2010 Jul;30(5):450-6. doi: 10.1002/jat.1516.
5
Correlations of water quality parameters with mutagenicity of chlorinated drinking water samples.水质参数与氯化饮用水样品致突变性的相关性。
J Toxicol Environ Health A. 2009;72(7):461-7. doi: 10.1080/15287390802608940.
6
Integrated disinfection by-products mixtures research: assessment of developmental toxicity in Sprague-Dawley rats exposed to concentrates of water disinfected by chlorination and ozonation/postchlorination.综合消毒副产物混合物研究：对暴露于氯化消毒和臭氧/后氯化消毒的水浓缩物中的斯普拉格-道利大鼠发育毒性的评估。
J Toxicol Environ Health A. 2008;71(17):1216-21. doi: 10.1080/15287390802182623.
7
Integrated disinfection by-products (DBP) mixtures research: gene expression alterations in primary rat hepatocyte cultures exposed to DBP mixtures formed by chlorination and ozonation/postchlorination.综合消毒副产物（DBP）混合物研究：原代大鼠肝细胞培养物中基因表达的改变，该培养物暴露于由氯化和臭氧化/后氯化形成的DBP混合物中。
J Toxicol Environ Health A. 2008;71(17):1195-215. doi: 10.1080/15287390802182581.
8
Dichloroacetate- and trichloroacetate-induced phagocytic activation and production of oxidative stress in the hepatic tissues of mice after acute exposure.急性暴露后二氯乙酸和三氯乙酸诱导小鼠肝组织中的吞噬细胞活化及氧化应激产生
J Biochem Mol Toxicol. 2008 Feb;22(1):27-34. doi: 10.1002/jbt.20210.
9
Perturbation of cytochrome P450, generation of oxidative stress and induction of DNA damage in Cyprinus carpio exposed in situ to potable surface water.原位暴露于饮用水源地表水的鲤鱼细胞色素P450的扰动、氧化应激的产生及DNA损伤的诱导。
Mutat Res. 2007 Jan 10;626(1-2):143-54. doi: 10.1016/j.mrgentox.2006.09.010. Epub 2006 Dec 1.
10
Developmental toxicity of mixtures: the water disinfection by-products dichloro-, dibromo- and bromochloro acetic acid in rat embryo culture.混合物的发育毒性：大鼠胚胎培养中氯乙酸、二溴乙酸和溴氯乙酸等水消毒副产物
Reprod Toxicol. 2004 Nov;19(1):111-6. doi: 10.1016/j.reprotox.2004.06.005.