亚慢性染毒后水氯化副产物二氯乙酸盐和三氯乙酸盐混合物对小鼠吞噬作用的诱导激活。
The induction of phagocytic activation by mixtures of the water chlorination by-products, dichloroacetate- and trichloroacetate, in mice after subchronic exposure.
机构信息
College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Toledo, OH 43614-2598, USA.
出版信息
J Biochem Mol Toxicol. 2013 Apr;27(4):237-42. doi: 10.1002/jbt.21476. Epub 2013 Feb 21.
Abstract
In this study, groups of B6C3F1 male mice were treated with dichloroacetate (DCA), trichloroacetate (TCA), and mixtures of the compounds (Mix I, II, and III) daily by gavage, for 13 weeks. The tested doses were 7.5, 15, and 30 mg DCA/kg/day and 12.5, 25, and 50 mg TCA/kg/day. The DCA: TCA ratios in Mix I, II, and III were 7.5:12.5, 15:25, and 30:50 mg/kg/day, respectively. Peritoneal lavage cells were collected at the end of the treatment period and assayed for the biomarkers of phagocytic activation, including superoxide anion and tumor necrosis factor-alpha production, and myeloperoxidase activity. The mixtures produced nonlinear effects on the biomarkers of phagocytic activation, with Mix I and II effects were found to be additive, but Mix III effects were found to be less than additive.
摘要
在这项研究中，B6C3F1 雄性小鼠经灌胃每日接受二氯乙酸（DCA）、三氯乙酸（TCA）和化合物混合物（混合物 I、II 和 III）处理，共 13 周。测试剂量分别为 DCA 7.5、15 和 30mg/kg/天和 TCA 12.5、25 和 50mg/kg/天。混合物 I、II 和 III 中 DCA:TCA 的比例分别为 7.5:12.5、15:25 和 30:50mg/kg/天。在治疗期末收集腹腔灌洗细胞，并测定吞噬细胞激活的生物标志物，包括超氧阴离子和肿瘤坏死因子-α的产生以及髓过氧化物酶活性。混合物对吞噬细胞激活的生物标志物产生非线性影响，混合物 I 和 II 的作用被发现是相加的，但混合物 III 的作用被发现小于相加。
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本文引用的文献
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