López Barroso Reinaldo, Macias Navarro Meidys María, Guzmán Tirado María G, Alvarez Vera Mayling
Hospital General "Dr. Juan Bruno Zayas Alfonso", Santiago de Cuba, Cuba.
Rev Cubana Med Trop. 2011 May-Aug;63(2):141-6.
several dengue outbreaks have taken place in Santiago de Cuba province in the last few years, in which pregnant women have been involved.
to determine the immunity and to describe the role of dengue infection and its sequence.
an observational and descriptive study was conducted to characterize dengue immunity in mothers and children after 10 and 12 months of birth and to determine the influence of certain viral infection sequences in pregnant women who suffered this disease during the dengue 3 epidemics in Santiago de Cuba. To this end, serum samples from 25 females tested dengue 3-positive and from children born to them after 10 and 12 months of childbirth were studied. IgG titers and viral infection sequences were determined and analyzed according to the World Health Organization dengue classification criteria.
the children did not present with the antibodies and the viral infection sequences associated to mothers; in order of frequency, the same percentage was observed in DEN2/DEN3, DEN1/DEN2/DEN3 (21,74 %); but lower percentage in DEN1/DEN3 (17,39 %).
the children did not develop humoral immunity (IgG) despite some manifestations inherent to the disease. The secondary infections prompted the most serious forms of the disease.
在过去几年中，古巴圣地亚哥省发生了几起登革热疫情，其中涉及孕妇。
确定免疫力，并描述登革热感染及其序列的作用。
进行了一项观察性和描述性研究，以表征母亲和儿童在出生10个月和12个月后的登革热免疫力，并确定在古巴圣地亚哥登革热3疫情期间感染此病的孕妇中某些病毒感染序列的影响。为此，研究了25名登革热3检测呈阳性的女性及其分娩10个月和12个月后所生孩子的血清样本。根据世界卫生组织登革热分类标准确定并分析IgG滴度和病毒感染序列。
儿童未出现与母亲相关的抗体和病毒感染序列；按频率排序，在DEN2/DEN3、DEN1/DEN2/DEN3中观察到相同百分比（21.74%）；但在DEN1/DEN3中百分比更低（17.39%）。
尽管疾病存在一些固有表现，但儿童并未产生体液免疫（IgG）。二次感染引发了最严重的疾病形式。
