Fernández R, Rodríguez T, Borbonet F, Vázquez S, Guzmán M G, Kouri G
Instituto de Medicina Tropical Pedro Kouri.
Rev Cubana Med Trop. 1994;46(2):76-8.
The current worldwide situation of dengue infection, and particularly in the American continent, is analyzed taking into account the increasing risk for infection during pregnancy which exists in endemic areas; the consequences of an eventual vertical transmission of the virus are practically unknown yet. We studied 59 women who gave birth to their children between 5 and 9 months after the "peak phase" of the type 2 dengue virus epidemic which broke out in Cuba in 1981. Sera of the mothers and newborns were studied through various serologic techniques in order to detect antibodies; in some cases we tried to isolate the virus, without success, from serum samples taken from the newborns; among these, we found 4 cases with positive IgM. These newborns showed neither apparent fetal damage at birth nor further alterations in a follow-up carried out when they reached 5 years of age. The need of carrying out further studies contributing to establish an adequate management of pregnant women infected by dengue virus is discussed.
考虑到流行地区孕妇感染风险增加，分析了当前全球登革热感染情况，尤其是美洲大陆的情况；病毒最终垂直传播的后果实际上仍不清楚。我们研究了59名在1981年古巴爆发的2型登革热病毒疫情“高峰期”后5至9个月分娩的妇女。通过各种血清学技术研究母亲和新生儿的血清，以检测抗体；在某些情况下，我们试图从新生儿采集的血清样本中分离病毒，但未成功；在这些样本中，我们发现4例IgM呈阳性。这些新生儿出生时既没有明显的胎儿损伤，在5岁时进行的随访中也没有进一步的异常。讨论了开展进一步研究以建立对感染登革热病毒孕妇的适当管理的必要性。
